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At the time the article was created Francis Deng had no recorded disclosures.View Francis Deng's current disclosures
At the time the article was last revised Daniel J Bell had no recorded disclosures.View Daniel J Bell's current disclosures
The iris sign is the imaging appearance of deep medullary venous thrombosis/congestion-related white matter injury in neonates created by fan-shaped, outwards radiating hemorrhages or cytotoxic edema in the subcortical and periventricular cerebral white matter. The appearance resembles the flower of the iris plant.
The sign is recognized on multiple modalities 1-4. On cranial ultrasound, the affected areas appear hyperechoic. On non-contrast CT, they appear hyperattenuating. Susceptibility weighted imaging and diffusion weighted MR imaging demonstrate hypointensities and hyperintensities, respectively, in this configuration.
The iris sign commonly occurs in association with subpial hemorrhage 2, suggesting a common pathophysiology.
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