Citation, DOI, disclosures and article data
Citation:
Weerakkody Y, Campos A, Knipe H, et al. Isolated cleft palate. Reference article, Radiopaedia.org (Accessed on 19 Apr 2024) https://doi.org/10.53347/rID-14889
An isolated cleft palate is a type of facial cleft. This is a much rarer occurrence than a cleft lip +/- palate and is thought to represent a different pathological entity.
The estimated incidence is at ~1 per 2000-2500 pregnancies 4-5. There may be a slight female predilection 4.
The cleft can involve either the soft or hard palate and may extend as far as the nasopalatine foramen but there is no accompanying cleft lip.
Associations
Ultrasound
An isolated cleft palate only rarely identified prenatally. An "absent equals sign" has been proposed as a novel marker where a normal uvula could be visualized with a typical echo pattern (the 'equals sign') in normal cases 7.
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1. Johnson D, Pretorius D, Budorick N et al. Fetal Lip and Primary Palate: Three-Dimensional Versus Two-Dimensional US. Radiology. 2000;217(1):236-9. doi:10.1148/radiology.217.1.r00oc18236 - Pubmed
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2. Diana W. Bianchi, Timothy M. Crombleholme, Mary E. D'Alton. Fetology. (2000) ISBN: 9780838525708 - Google Books
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3. Samuel Berkowitz. Cleft Lip and Palate. (2006) ISBN: 3540234098 - Google Books
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4. Stephen S. Park. Facial Plastic Surgery. (2005) ISBN: 9781588903198 - Google Books
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5. Stroustrup smith A, Estroff JA, Barnewolt CE et-al. Prenatal diagnosis of cleft lip and cleft palate using MRI. AJR Am J Roentgenol. 2004;183 (1): 229-35. AJR Am J Roentgenol (full text) - Pubmed citation
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6. Holmes LB, Baldwin EJ, Smith CR et-al. Increased frequency of isolated cleft palate in infants exposed to lamotrigine during pregnancy. Neurology. 2008;70 (22): 2152-8. doi:10.1212/01.wnl.0000304343.45104.d6 - Pubmed citation
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7. Wilhelm L & Borgers H. The 'Equals Sign': A Novel Marker in the Diagnosis of Fetal Isolated Cleft Palate. Ultrasound Obstet Gynecol. 2010;36(4):439-44. doi:10.1002/uog.7704 - Pubmed
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8. Shaikh D, Mercer NS, Sohan K et-al. Prenatal diagnosis of cleft lip and palate. Br J Plast Surg. 2001;54 (4): 288-9. doi:10.1054/bjps.2001.3575 - Pubmed citation
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9. Wayne C, Cook K, Sairam S, Hollis B, Thilaganathan B. Sensitivity and Accuracy of Routine Antenatal Ultrasound Screening for Isolated Facial Clefts. Br J Radiol. 2002;75(895):584-9. doi:10.1259/bjr.75.895.750584 - Pubmed
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