Juvenile granulosa cell tumour (ovary)
It typically occurs in premenarchal girls and young women. The mean age of presentation is 13 years.
JGCTs typically produce precocious puberty as a consequence of oestrogen secretion. Rarely, they produce androgenic hormones.
Uterine enlargement and/or endometrial thickening may be present.
- appearance varies widely: may appear anywhere from a solid mass, to a multiloculated solid and cystic mass, to a purely cystic lesion
- varying degrees of hemorrhage and/or fibrosis
- typically unilateral
- less likely to have intracystic papillary projections than epithelial ovarian tumours
- "sponge-like" appearance
- solid areas of intermediate T2 signal intensity
- multilocular cystic component
- increased T1 signal in multiple locules, compatible with haemorrhage into the cystic locule
Treatment and prognosis
Most JGCTs (~90%) are detected at a low stage and surgery is curative. Higher stage disease has a worse prognosis and may require chemotherapy 7.
Inhibin can be used as a serum marker for diagnosis and post-treatment follow up.
- 1. Young RH, Dickersin GR, Scully RE. Juvenile granulosa cell tumor of the ovary. A clinicopathological analysis of 125 cases. Am. J. Surg. Pathol. 1984;8 (8): 575-96. - Pubmed citation
- 2. Gittleman AM, Price AP, Coren C et-al. Juvenile granulosa cell tumor. Clin Imaging. 27 (4): 221-4. Clin Imaging (link) - Pubmed citation
- 3. Imaoka I, Wada A, Kaji Y et-al. Developing an MR imaging strategy for diagnosis of ovarian masses. Radiographics. 26 (5): 1431-48. doi:10.1148/rg.265045206 - Pubmed citation
- 4. Reed N. Rare and Uncommon Gynecological Cancers, A Clinical Guide. Springer Verlag. (2010) ISBN:3642134912. Read it at Google Books - Find it at Amazon
- 5. Dähnert W. Radiology Review Manual. Lippincott Williams & Wilkins. (2011) ISBN:1609139437. Read it at Google Books - Find it at Amazon
- 6. Bouffet E, Basset T, Chetail N et-al. Juvenile granulosa cell tumor of the ovary in infants: a clinicopathologic study of three cases and review of the literature. J. Pediatr. Surg. 1997;32 (5): 762-5. J. Pediatr. Surg. (link) - Pubmed citation
- 7. Heo SH, Kim JW, Shin SS et-al. Review of ovarian tumors in children and adolescents: radiologic-pathologic correlation. Radiographics. 2014;34 (7): 2039-55. doi:10.1148/rg.347130144 - Pubmed citation