Juvenile granulosa cell tumor (ovary)

Radswiki et al.

Juvenile granulosa cell tumors of the ovary (JGCT) are a less common subtype of granulosa cell tumor of the ovary (~5% of cases). They are classified as ovarian sex cord / stromal tumors.

It typically occurs in premenarchal girls and young women. The mean age of presentation is 13 years.

JGCTs typically produce precocious puberty as a consequence of estrogen secretion. Rarely, they produce androgenic hormones.

Uterine enlargement and/or endometrial thickening may be present.

  • appearance varies widely: may appear anywhere from a solid mass, to a multiloculated solid and cystic mass, to a purely cystic lesion
  • varying degrees of hemorrhage and/or fibrosis
  • typically unilateral
  • less likely to have intracystic papillary projections than epithelial ovarian tumors
  • "sponge-like" appearance 
    • solid areas of intermediate T2 signal intensity
    • multilocular cystic component
    • increased T1 signal in multiple locules, compatible with hemorrhage into the cystic locule

Most JGCTs (~90%) are detected at a low stage and surgery is curative. Higher stage disease has a worse prognosis and may require chemotherapy 7.

Inhibin can be used as a serum marker for diagnosis and post-treatment follow up.

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Article information

rID: 15469
Synonyms or Alternate Spellings:
  • Juvenile granulosa cell tumours of ovary
  • Juvenile granulosa cell tumor of ovary
  • Juvenile granulosa cell tumors of ovary
  • Juvenile ovarian granulosa cell tumours.
  • Ovarian granulosa cell tumour - juvenile type
  • Juvenile type granuosa cell tumour of the ovary
  • Juvenile granulosa cell tumour of ovary
  • Juvenile granulosa cell tumour of the ovaries

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