Citation, DOI, disclosures and article data
Citation:
Radswiki T, Yap J, Morgan M, et al. Juvenile granulosa cell tumor (ovary). Reference article, Radiopaedia.org (Accessed on 08 Nov 2024) https://doi.org/10.53347/rID-15469
Juvenile granulosa cell tumors of the ovary (JGCT) are a less common subtype of granulosa cell tumor of the ovary (~5% of cases). They are classified as ovarian sex cord / stromal tumors.
It typically occurs in premenarchal girls and young women. The mean age of presentation is 13 years.
Associations
Juvenile granulosa cell tumors of the ovary typically produce precocious puberty as a consequence of estrogen secretion. Rarely, they produce androgenic hormones.
Ultrasound
the appearance varies widely: may appear anywhere from a solid ovarian mass, to a multiloculated solid and cystic mass, to a purely cystic lesion
varying degrees of hemorrhage and/or fibrosis
typically unilateral
less likely to have intracystic papillary projections than epithelial ovarian tumors
MRI
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"sponge-like" appearance
solid areas of intermediate T2 signal intensity
multilocular cystic component
increased T1 signal in multiple locules, compatible with hemorrhage into the cystic locule
Uterine enlargement and/or endometrial thickening may also be present.
Treatment and prognosis
Most juvenile granulosa cell tumors of the ovary (~90%) are detected at a low stage and surgery is curative. Higher-stage disease has a worse prognosis and may require chemotherapy 7.
Inhibin can be used as a serum marker for diagnosis and post-treatment follow-up.
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1. Young RH, Dickersin GR, Scully RE. Juvenile granulosa cell tumor of the ovary. A clinicopathological analysis of 125 cases. Am. J. Surg. Pathol. 1984;8 (8): 575-96. - Pubmed citation
-
2. Gittleman AM, Price AP, Coren C et-al. Juvenile granulosa cell tumor. Clin Imaging. 27 (4): 221-4. Clin Imaging (link) - Pubmed citation
-
3. Imaoka I, Wada A, Kaji Y et-al. Developing an MR imaging strategy for diagnosis of ovarian masses. Radiographics. 26 (5): 1431-48. doi:10.1148/rg.265045206 - Pubmed citation
-
4. Reed N. Rare and Uncommon Gynecological Cancers, A Clinical Guide. Springer Verlag. (2010) ISBN:3642134912. Read it at Google Books - Find it at Amazon
-
5. Dähnert W. Radiology Review Manual. Lippincott Williams & Wilkins. (2011) ISBN:1609139437. Read it at Google Books - Find it at Amazon
-
6. Bouffet E, Basset T, Chetail N et-al. Juvenile granulosa cell tumor of the ovary in infants: a clinicopathologic study of three cases and review of the literature. J. Pediatr. Surg. 1997;32 (5): 762-5. J. Pediatr. Surg. (link) - Pubmed citation
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7. Heo SH, Kim JW, Shin SS et-al. Review of ovarian tumors in children and adolescents: radiologic-pathologic correlation. Radiographics. 2014;34 (7): 2039-55. doi:10.1148/rg.347130144 - Pubmed citation
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