Kernohan notch phenomenon is an imaging finding resulting from extensive midline shift due to mass effect, resulting in indentation in the contralateral cerebral crus by the tentorium cerebelli. This has also been referred to as Kernohan-Woltman notch phenomenon and false localising sign.
The integrity of the crus cerebri and its descending corticospinal tracts is disturbed, and a contralateral (to crus cerebri) motor deficit is produced with a deteriorating level of consciousness. A hemiparesis ipsilateral to the expanding mass is known as Kernohan phenomenon, which is a false localising sign.
Transtentorial herniation is a well-described neurologic phenomenon caused by an expanding supratentorial mass/lesion. Uncal herniation is a common subtype of transtentorial herniation in which the innermost part of the temporal lobe, the uncus, can be squeezed so much that it goes by the tentorium and puts pressure on the brainstem, most notably the midbrain.
Compressive forces cause the cerebral peduncle of the midbrain to impinge on the contralateral edge of the tentorium cerebelli, forming an indentation in the crus known as Kernohan's notch. With time, the integrity of the crus cerebri and its descending corticospinal tracts is disturbed, and a contralateral (to crus cerebri) motor deficit is produced with a deteriorating level of consciousness.
Kernohan notch is demonstrated on cross-sectional imaging of the brain and is best seen in the coronal plane.
On CT it is usually possible to show the mass effect of a tumor on the brain stem, but identification of an uncal herniation is much harder with CT.
MRI with its ability to image the brain in multiple planes and excellent resolution of the brainstem can reveal a deformity or injury of the cerebral peduncle resulting from a transtentorial herniation.
History and etymology
The phenomenon was described by James Watson Kernohan (1896-1981), an Irish-born American pathologist in 1929 after an autopsy study revealed a notched cerebral peduncle from a contralateral herniation syndrome.
- 1. Zafonte RD, Lee CY. Kernohan-Woltman notch phenomenon: an unusual cause of ipsilateral motor deficit. Arch Phys Med Rehabil. 1997;78 (5): 543-5. Arch Phys Med Rehabil (link) - Pubmed citation
- 2. Yousem DM, Zimmerman RD, Grossman RI. Neuroradiology. Mosby. (2010) ISBN:0323045219. Read it at Google Books - Find it at Amazon
- 3. Moon KS, Lee JK, Joo SP et-al. Kernohan's notch phenomenon in chronic subdural hematoma: MRI findings. J Clin Neurosci. 2007;14 (10): 989-92. doi:10.1016/j.jocn.2006.05.016 - Pubmed citation
- 4. Yoo WK, Kim DS, Kwon YH et-al. Kernohan's notch phenomenon demonstrated by diffusion tensor imaging and transcranial magnetic stimulation. J. Neurol. Neurosurg. Psychiatr. 2008;79 (11): 1295-7. doi:10.1136/jnnp.2007.138131 - Pubmed citation
- 5. Etienne D, Zurada A, Matusz P, Shoja MM, Tubbs RS, Loukas M. James Watson Kernohan (1896–1981: Frontiers in neuropathology. Clinical anatomy (New York, N.Y.). 25 (4): 527-9. doi:10.1002/ca.22000 - Pubmed