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The kidneys are paired retroperitoneal organs that lie at the level of the T12 to L3 vertebral bodies.
The kidneys are located on the posterior abdominal wall, with one on either side of the vertebral column, in the perirenal space. The long axis of the kidney is parallel to the lateral border of the psoas muscle and lies on the quadratus lumborum muscle. In addition, the kidneys lie at an oblique angle, that is the superior renal pole is more medial and posteriorly than the inferior pole. Due to the right lobe of the liver, the right kidney usually lies slightly lower than the left kidney 16.
In adults, the normal kidney is 10-14 cm long in males and 9-13 cm long in females, 3-5 cm wide, 3 cm in antero-posterior thickness and weighs 150-260 g. The left kidney is usually slightly larger than the right.
The kidney is bean-shaped with a superior and an inferior pole, anterior and posterior surfaces, and lateral and medial borders. The midportion of the kidney is often called the midpole.
The kidney has a fibrous capsule, which is surrounded by perirenal fat. The kidney itself can be divided into renal parenchyma, consisting of renal cortex and medulla, and the renal sinus containing renal pelvis, calyces, renal vessels, nerves, lymphatics and perirenal fat.
The renal parenchyma has two layers: cortex and medulla. The renal cortex lies peripherally under the capsule while the renal medulla consists of 10-14 renal pyramids, which are separated from each other by an inward extension of the renal cortex called renal columns.
Urine is produced in the renal lobes, which consists of the renal pyramid with the associated overlying renal cortex and adjacent renal columns. Each renal lobe drains at a papilla into a minor calyx, four or five of these unite to form a major calyx. Each kidney normally has two or three major calyces, which unite to form the renal pelvis.
The renal hilum is the entry to the renal sinus and lies vertically at the anteromedial aspect of the kidney. It contains the renal vessels and nerves, fat and the renal pelvis, which typically emerges posterior to the renal vessels, with the renal vein being anterior to the renal artery.
filter the blood to remove excess water, minerals, and waste products of protein metabolism, producing urine in the process
are involved in
blood pressure regulation
regulation of body fluid volume, osmolality and pH
vitamin D and red blood cell (RBC) production
Tests of renal function include:
estimated glomerular filtration rate (eGFR)
blood urea nitrogen (BUN) or urea
creatinine levels and creatinine clearance
cystatin C levels
diaphragm (upper pole of the kidney)
parietal pleura through costal parts of diaphragm and lumbocostal trigone
parietal pleura that extends below 12th rib through lumbar part of diaphragm in costovertebral angle
11th rib related to left kidney only (through costophrenic recess and diaphragm), 12th rib (directly)
lateral and medial lumbocostal arches (arcuate lines)
bare area of the liver (upper pole)
posterior portion of the right coronary ligament of liver (hepatorenal ligament)
right lobe of the liver
D2 duodenum (medial margin of the kidney)
right colic flexure (just above inferior pole)
omental bursa/lesser sac (upper pole)
spleen (lateral margin)
tail of the pancreas (hilum)
loops of jejunum in the left infracolic compartment (lower pole)
left colic flexure and descending colon (lateral to lower pole)
See article: developmental anomalies of the kidney and ureter.
Kidney length should not be less than three vertebral body lengths, and no more than four vertebral body lengths 10.
On unenhanced CT the renal pyramids can appear hyperdense 7 (see: white pyramid sign).
Antenatally, fetal kidneys show varying texture depending on gestational age. It is echogenic in the first trimester, with decreasing echogenicity as the pregnancy progresses. Corticomedullary differentiation can be appreciated after 15 weeks of gestation but clear demarcation between cortex and medulla can be seen at 20 weeks. Renal echogenicity decreases compared to liver and spleen after 17 weeks 12.
Normal kidney appearance in adult 11:
cortex is less echogenic than the liver
medullary pyramids are slightly less echogenic than the cortex
cortex thickness equals/is more than 6 mm 14
if the pyramids are difficult to differentiate, the parenchymal thickness can be measured instead and should be 15-20 mm 11
central renal sinus, consisting of the calyces, renal pelvis and fat, is more echogenic than the cortex
renal pelvis may appear as a central slit of anechoic fluid at the hilum
normal ureters are generally not well seen on ultrasound
The collecting system arises from the ureteric bud, which arises from the mesonephric duct in the fourth week of gestation. The renal parenchyma arises from the metanephros, which appears in the fifth week, a derivative of the intermediate mesoderm 15.
The ureteric bud penetrates the metanephric mesoderm, which forms as a cup-shaped tissue cap. The ureteric bud dilates and subdivides to form twelve or so generations of tubules with the first generations fusing to form the renal pelvis, major and minor calyces, and renal pyramids with the later generations forming approximately a million renal tubules 15.
Under the regulation of complex signaling pathways, the ureteric bud incites the metanephric tissue to form small renal vesicles that eventually form primitive S-nephrons which are invaginated by endothelial cells from nearby angioblasts; before going on to form the definitive nephron 15. Glomerular filtration begins at 9th week of gestation. Nephron development is complete at birth except in premature infants. The kidney matures functionally after birth 15.
The kidney develops in the pelvis but assumes its normal cranial abdominal location in adults due to disproportionate growth of the body in the lumbar and sacral regions 8-9.
A discrepancy of >2 cm between renal lengths should be considered abnormal 10 and may indicate an underlying disease. Common diseases affecting the kidneys include:
- 1. Clinically Oriented Anatomy. Lippincott Williams & Wilkins. ISBN:1451119453. Read it at Google Books - Find it at Amazon
- 2. Drake R, Vogl AW, Mitchell AWM. Gray's Basic Anatomy: with STUDENT CONSULT Online Access (Grays Anatomy for Students). Churchill Livingstone. ISBN:B0092DEQ1U. Read it at Google Books - Find it at Amazon
- 3. McMINN. Lasts Anatomy Regional and Applied. CHURCHILL LIVINGSTONE. (2003) ISBN:B0084AQDG8. Read it at Google Books - Find it at Amazon
- 4. Radiological Imaging of the Kidney (Medical Radiology / Diagnostic Imaging). Springer. ISBN:B008BBMC8I. Read it at Google Books - Find it at Amazon
- 5. Martini FH, Nath JL, Bartholomew EF. Fundamentals of Anatomy & Physiology with MasteringA&P. Benjamin Cummings. ISBN:0321719794. Read it at Google Books - Find it at Amazon
- 6. Dudek RW. High-yield kidney. Lippincott Williams & Wilkins. ISBN:0781755697. Read it at Google Books - Find it at Amazon
- 7. Step by Step in Emergency Radiology. Jaypee Brothers Medical Publishers. ISBN:818061803X. Read it at Google Books - Find it at Amazon
- 8. Longo D, Fauci A, Kasper D et-al. Harrison's Principles of Internal Medicine, 18th Edition. McGraw-Hill Professional. ISBN:007174889X. Read it at Google Books - Find it at Amazon
- 9. Sadler TW. Langman's Medical Embryology. LWW. ISBN:1451113420. Read it at Google Books - Find it at Amazon
- 10. Zagoria R. Genitourinary Radiology. Mosby. (2004) ISBN:0323018424. Read it at Google Books - Find it at Amazon
- 11. Marchal G, Verbeken E, Oyen R, Moerman F, Baert AL, Lauweryns J; Ultrasound of the normal kidney: a sonographic, anatomic and histologic correlation. Ultrasound Med Biol. 1986 Dec;12(12):999-1009. PMID: 3547990
- 12. Hindryckx A, De Catte L. Prenatal diagnosis of congenital renal and urinary tract malformations. Facts, views & vision in ObGyn. 3 (3): 165-74. Pubmed
- 13. Christopher Lote. Principles of Renal Physiology. ISBN: 9781461437857
- 14. El-Reshaid W, Abdul-Fattah H. Sonographic assessment of renal size in healthy adults. Medical principles and practice : international journal of the Kuwait University, Health Science Centre. 23 (5): 432-6. doi:10.1159/000364876 - Pubmed
- 15. Zweyer M. Embryology of the Kidney. Radiological Imaging of the Kidney. 2010;:3-15. doi:10.1007/978-3-540-87597-0_1
- 16. Stephanie Ryan, Michelle McNicholas, Stephen J. Eustace. Anatomy for Diagnostic Imaging. (2011) Pages 196-200. ISBN: 9780702029714 - Google Books