The Kirklin sign refers to a deformity of the normal gastric air bubble on an upright chest radiograph due to a mass lesion of the gastric cardia or fundus.
The differential for a Kirklin sign includes
- gastric tumour
- gastro-oesophageal varices
The Kirklin sign is different from the Kirklin complex, a gastric finding on upper GI fluoroscopy.
History and etymology
Byrl Raymond Kirklin, (1888-1957) an American radiologist described this finding in 1939 1,2.
- 1. Kirklin BR. Roentgenologic diagnosis of cancer of the cardia. AJR 1939; 41:873-880.
- 2. Gurney JW, Olson DL, Schroeder BA. The gastric bubble: roentgen observations. Radiographics. 1989;9 (3): 467-85. doi:10.1148/radiographics.9.3.2727356 - Pubmed citation
- 3. Jenkinson EL. Byrl Raymond Kirklin, M.D., 1888–1957. Radiology 1957;68:877-878. https://doi.org/10.1148/68.6.877