Korean Society of Thyroid Radiology Thyroid Imaging, Reporting and Data System (K-TIRADS)
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At the time the article was created Derek Smith had no recorded disclosures.View Derek Smith's current disclosures
At the time the article was last revised Jeremy Jones had no recorded disclosures.View Jeremy Jones's current disclosures
K-TIRADS is a reporting system designed by the Korean Society of Thyroid Radiology for ultrasound assessment of thyroid nodules and stratification of the requirement for FNA and malignancy. There is also stratification of indications for lymph node sampling.
This is a five-stage system using descriptive, pattern recognition findings on ultrasound, and size measurement.
A number of established benign nodules features (purely cystic/anechoic, comet tail artefact, spongiform) are included in the benign K-TIRADS 2 group.
Assessment of echogenicity, shape/contour and three specific suspicious ultrasound features (microcalcifications, nonparallel orientation [taller than wide], spiculated / microlobulated margin) determine categorization.
Partially cystic or isohyperechoic nodules are considered lower risk than solid hypoechoic nodules.
- K-TIRADS 1: no nodule
- K-TIRADS 2: benign
- K-TIRADS 3 (low): partially cystic / isohyperechoic with no suspicious features
- K-TIRADS 4 (intermediate): as for K-TIRADS 3 but with any suspicious features or as for K-TIRADS 5 without suspicious features
- K-TIRADS 5 (high): solid hypoechoic nodule with any suspicious features
Use of FNA / sampling is a combination of the suspicion above and size, unless there are obvious poor prognostic factors (extrathyroid extension or known distant metastases).
K-TIRADS 2: if a spongiform nodule is ≥2 cm FNA is recommended.
- biopsy may still become necessary if e.g. surgery or ablation therapy is required
- K-TIRADS 3: ≥1.5 cm
- K-TIRADS 4: ≥1 cm
- K-TIRADS 5: ≥1 cm (in select cases >0.5 cm)
- biopsy should be performed regardless the nodule size if extrathyroid extension or nodal metastasis is suspected
Risk of malignancy
The overall risk of malignancy in the original 2016 paper was 0% for K-TIRADS 2, 7.8% for K-TIRADS 3, 25.4% for K-TIRADS 4 and 79.3% for K-TIRADS 5.
Sensitivity for malignancy for each stage is:
- K-TIRADS 2: 0%
- K-TIRADS 3: 19.2%
- K-TIRADS 4: 29.5%
- K-TIRADS 5: 51.3%
Comparison with other classification systems
A number of comparative studies of the systems 2-5 show the KSThR system has high sensitivity (71-95%) but variable-to-poor specificity (53-67%). The threshold for FNA / sampling is lower than most other systems, which results in high pick up rates but also consistently high unnecessary FNA rates, with only a 41% accuracy 3.
Excellent interobserver agreement regarding the decision to biopsy has been shown (Cohen kappa 0.82) 5.
K-TIRADS, unlike the ACR-TI-RADS and EU-TIRADS systems has no recommendations for follow-up without FNA, as its reliability in preventing progression into nodal/distant metastasis formation is considered controversial 1.
Lymph node assessment
K-TIRADS also describes the assessment of cervical lymph nodes which can be interrogated at the same time as thyroid lesions, both on ultrasound and CT.
Benign features include a normal hilar fatty echo and vascular pattern. Intermediate features include the loss of normal hilar structures and suspicious nodes show cystic/necrotic change, micro or macrocalcification, hyperechogenicity and abnormal peripheral or diffuse vasculature.
FNA is recommended for suspicious nodes >3 mm and intermediate nodes >5 mm (short diameter).
The following key signs of extrathyroid extension can be observed on ultrasound 1:
- capsular protrusion: the mass/nodule is bulging into the adjacent tissues causing the loss of the normal tissue boundaries.
- capsular disruption: loss of the perithyroidal echogenic line where the thyroid nodule/mass contacts it.
- capsular abutment: no tissue in between the thyroid lesion and the thyroid capsule.
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