KRAS mutation

Last revised by Rohit Sharma on 17 Nov 2021

Citation, DOI, disclosures and article data

Citation:

Weerakkody Y, Sharma R, Hacking C, et al. KRAS mutation. Reference article, Radiopaedia.org (Accessed on 19 Apr 2024) https://doi.org/10.53347/rID-69168

DOI:

https://doi.org/10.53347/rID-69168

Permalink:

https://radiopaedia.org/articles/69168

rID:

69168

Article created:

1 Jul 2019, Yuranga Weerakkody ◉

Disclosures:

At the time the article was created Yuranga Weerakkody had no recorded disclosures.

View Yuranga Weerakkody's current disclosures

Last revised:

17 Nov 2021, Rohit Sharma ◉

Disclosures:

At the time the article was last revised Rohit Sharma had no recorded disclosures.

View Rohit Sharma's current disclosures

Revisions:

8 times, by 5 contributors - see full revision history and disclosures

Systems:

Chest, Gastrointestinal, Hepatobiliary, Oncology

Sections:

Pathology

Synonyms:

Kirsten-ras (KRAS) mutation
KRAS mutations
K-RAS mutations

KRAS (shortened name for the gene Kirsten RAt Sarcoma viral oncogene homolog) mutations are associated in a number of malignancies including:

Several germline KRAS mutations have also been found to be associated with some syndromes such as:

The gene provides instructions for a protein called K-Ras, which is part of a signaling pathway (RAS/MAPK pathway), instructing the cell to grow and divide, or to mature and take on specialized functions (i.e. differentiate).