Löfgren syndrome is a specific acute clinical presentation of systemic sarcoidosis, consisting of:
- constitutional symptoms
- erythema nodosum
- hilar adenopathy: see thoracic manifestations of sarcoidosis
- arthritis: see musculoskeletal manifestations of sarcoidosis
- uveitis (occasionally)
- parotitis (occasionally)
Make a note not to confuse this syndrome with Löffler syndrome, as the names are quite similar but the conditions quite different.
Treatment and prognosis
Compared to run-of-the-mill sarcoidosis, patients presenting with Löfgren syndrome typically have a better overall prognosis with a self-limited clinical course and spontaneous remission.
History and etymology
It was initially described by S Lofgren in 1952 2.
- 1. Miller BH, Rosado-de-christenson ML, Mcadams HP et-al. Thoracic sarcoidosis: radiologic-pathologic correlation. Radiographics. 1995;15 (2): 421-37. Radiographics (abstract) - Pubmed citation
- 2. Lofgren S, Lundback H. The bilateral hilar lymphoma syndrome; a study of the relation to age and sex in 212 cases. Acta Med Scand. 1952;142 (4): 259-64. - Pubmed citation
- systemic manifestations
- pulmonary and mediastinal manifestations (chest x-ray staging)
- cardiac manifestations
- musculoskeletal manifestations
- head and neck manifestations
- central nervous system manifestations
- abdominal manifestations
- cutaneous manifestations