Labyrinthitis ossificans

Labyrinthitis ossificans (LO), also known as labyrinthine ossification, represents pathological ossification of the membranous labyrinth as a response to an insult to the inner ear.

It is usually associated with profound sensorineural hearing loss

It most commonly results from an inflammatory process of the inner ear, but it can be associated with temporal bone trauma, temporal bones tumours or autoimmune inner ear disease.

High-density bone deposition within the membranous labyrinth:

  • mild LO: hazy increase in density within fluid spaces of the membranous labyrinth
  • moderate LO: focal areas of bony encroachment on fluid spaces of the membranous labyrinth
  • severe LO: membranous labyrinth completely obliterated by bone replacing fluid spaces
  • T2: may show low-intensity foci within high signal fluid of inner ear

It may complicate or preclude cochlear implantation.

Possible imaging differential considerations include:

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Article information

rID: 21787
System: Head & Neck
Section: Pathology
Synonyms or Alternate Spellings:
  • Labyrinthine ossification
  • Ossifying labyrinthitis
  • Chronic labyrinthitis

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Cases and figures

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    Labyrinthitis oss...
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    Coronal MIP view.
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    Case 3: MRI
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    Case 3: CT
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