Lady Windermere syndrome
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Lady Windermere syndrome refers to a pattern of pulmonary Mycobacterium avium complex (MAC) infection seen typically in elderly white women who chronically suppress the normal cough reflex. A fastidious nature and a reticence to expectorate are believed to predispose such persons to infections with MAC.
Linear opacities in middle lobe or lingula can be seen, as a result of subsegmental atelectasis or bronchiectasis with mucosal impactions. Residual middle lobe or lingula atelectasis can also be seen.
Typical manifestation is of bronchiectasis, centrilobular nodules, tree-in-bud nodularity and eventual scarring and volume loss affecting the middle lobe and lingula 1.
It is one of the causes of right middle lobe syndrome.
History and etymology
The syndrome is named after Lady Windermere, a character in Oscar Wilde's 1892 play 'Lady Windermere's Fan' 2.
- 1. Müller NL, Franquet T, Lee KS et-al. Imaging of pulmonary infections. Lippincott Williams & Wilkins. (2007) ISBN:078177232X. Read it at Google Books - Find it at Amazon
- 2. Mycobacterium avium-intracellulare infection from Wikipedia, the free encyclopedia. Mycobacterium avium-intracellulare infection