Langer Giedion syndrome

Dr Henry Knipe and Dr Yuranga Weerakkody et al.

Langer-Giedion syndrome (LGS), also known as trichorhinophanageal syndrome type II, is an extremely rare autosomal dominant genetic disorder.


The effects are seen mainly on the skeletal system and primarily involves

  • hair: tricho
  • nose: rhino
  • digits of the hands and feet: phalangeal

There can be however multiple of other features such as:

  • multiple exostoses
  • mental retardation
  • lose redundant skin

It occurs from a deletion within chromosome 8.

History and etymology

Named after 2,3:

  • Andreas Giedion, Swiss radiologist
  • Leonard O Langer JrAmerican (US) radiologist 
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Article information

rID: 10592
Section: Syndromes
Synonyms or Alternate Spellings:
  • Trichorhinophanageal syndrome type II

Cases and figures

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