Langer-Giedion syndrome

Langer-Giedion syndrome, also known as trichorhinophalangeal syndrome type II, is an extremely rare autosomal dominant genetic disorder.


The effects are seen mainly on the skeletal system and primarily involves

  • hair: tricho
  • nose: rhino
  • digits of the hands and feet: phalangeal

There can be however multiple of other features such as:

  • multiple exostoses
  • intellectual disability
  • lose redundant skin

It occurs from a deletion within chromosome 8.

History and etymology

Named after 2,3:

  • Andreas Giedion, Swiss radiologist
  • Leonard O Langer Jr, American (US) radiologist 

Article information

rID: 10592
Section: Syndromes
Synonyms or Alternate Spellings:
  • Trichorhinophalangeal syndrome type II

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Cases and figures

  • Trichorhinophalan...
    Case 1
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