Larsen syndrome

Larsen syndrome (LS) is an extremely rare disorder, often classified as a type of osteochondrodysplasia.

The estimated incidence is thought to be at ~ 1 in 100,000 people. There may be an increased female predilection.

It is characterized by many features including:

There can be significant genetic heterogeneity. It is usually inherited as an autosomal dominant fashion while some autosomal recessive forms have also been described. The autosomal dominant form of Larsen syndrome is thought to be due to mutations in a gene called LAR1, on the short arm of chromosome 3.

The condition was first described in a 1950 journal report by L. J. Larsen, et al.

Share article

Article information

rID: 14624
Section: Syndromes
Synonyms or Alternate Spellings:
  • Larsen's syndrome
  • Larsen syndrome (LS)
  • Multiple congenital dislocation syndrome

Support Radiopaedia and see fewer ads

Cases and figures

  • Case 1
    Drag here to reorder.
  • Updating… Please wait.

     Unable to process the form. Check for errors and try again.

     Thank you for updating your details.