Citation, DOI & article data
Laryngomalacia is the most common cause of noisy breathing in infants where it results in stridor. It is the result of a congenital abnormality of the cartilage in the larynx that results in the dynamic partial supraglottic collapse of the larynx during breathing.
Most children present in early infancy with stridor. Symptoms are maximal around 6-8 months and the symptoms will have resolved in most by 12-24 months.
It may be associated with feeding difficulties in some patients and it is frequently seen in combination with gastro-esophageal reflux disease.
Laryngeal collapse occurs in the inspiratory phase of breathing when an anatomical abnormality results in intermittent upper airway obstruction and stridor.
The underlying anatomical abnormality is most commonly shortening of the aryepiglottic folds, resulting in side-to-side curling of the epiglottis. However, prolapse of supraglottic tissues into the laryngeal inlet during inspiration may also be the cause. The epiglottis, aryepiglottic folds and corniculate mounds of the arytenoids may be involved 1.
Some authors suggest that mucosal inflammation as the result of gastro-esophageal reflux disease (GERD) may also be an etiological consideration 2. Where there is suspicion of GERD, it should be treated.
The diagnostic investigation of choice is flexible laryngoscopy. Radiology is often not involved.
Patients may have chest radiographs because of associated chest findings, or upper-GI contrast studies to assess gastro-esophageal reflux disease. They may also have chest cross-sectional imaging or ultrasound to make an assessment of the subglottic space and exclude a subglottic lesion.
Treatment and prognosis
Treatment is largely supportive since most children show spontaneous resolution after 12-24 months. When associated gastro-esophageal reflux disease is present, that should be treated. Endoscopic supraglottoplasty may be required in severe cases where there is significant airway obstruction.
- 1. Loke D, Ghosh S, Panarese A, Bull PD. Endoscopic division of the ary-epiglottic folds in severe laryngomalacia. (2001) International journal of pediatric otorhinolaryngology. 60 (1): 59-63. Pubmed
- 2. Matthews BL, Little JP, Mcguirt WF, Koufman JA. Reflux in infants with laryngomalacia: results of 24-hour double-probe pH monitoring. (1999) Otolaryngology--head and neck surgery : official journal of American Academy of Otolaryngology-Head and Neck Surgery. 120 (6): 860-4. doi:10.1016/S0194-5998(99)70327-X - Pubmed