Citation, DOI, disclosures and article data
Citation:
Weerakkody Y, Luong D, Knipe H, Late-onset asthma. Reference article, Radiopaedia.org (Accessed on 13 Feb 2025) https://doi.org/10.53347/rID-70947
Late-onset asthma (LOA) is a form of asthma that precipitates in the adult or the elderly.
Epidemiology
The estimated age- and sex-adjusted incidence of newly diagnosed asthma in people older than 65 years at around 0.1% per year 1. There may be a greater female predilection.
Pathology
From a phenotypical perspective, late-onset asthma is divided into two types depending on the presence or absence of eosinophilic inflammation, T-helper (Th)2- and non-Th2-associated LOA. It is less often associated with allergy and atopic diseases
Treatment and prognosis
It is thought to have a low remission rate. Many patients with adult-onset asthma can have a poor prognosis with a faster decline in lung function 3.
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1. Hirano T, Matsunaga K. Late-onset asthma: current perspectives. (2018) Journal of asthma and allergy. 11: 19-27. doi:10.2147/JAA.S125948 - Pubmed
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2. Ash SY, Diaz AA. The role of imaging in the assessment of severe asthma. (2017) Current opinion in pulmonary medicine. 23 (1): 97-102. doi:10.1097/MCP.0000000000000341 - Pubmed
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3. Selma B. de Nijs, Lisette N. Venekamp, Elisabeth H. Bel. Adult-onset asthma: is it really different?. (2013) European Respiratory Review. 22 (127): 44. doi:10.1183/09059180.00007112 - Pubmed
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