Lateral pontine syndrome, also known as Marie-Foix syndrome or Marie-Foix-Alajouanine syndrome, refers to one of the brainstem stroke syndromes which occurs due to occlusion of perforating branches of the basilar and anterior inferior cerebellar (AICA) arteries 1,2. This results in infarction of the lateral aspect of the pons which produces a characteristic clinical picture from the involvement of the following pontine structures 1,2:
- corticospinal tract: contralateral hemiplegia/hemiparesis.
- spinothalamic tracts: contralateral loss of pain and temperature sensation.
- cerebellar tracts: ipsilateral limb ataxia.
- facial nerve (CN VII) nucleus: ipsilateral facial paralysis.
- vestibulocochlear nerve (CN VIII) nuclei: ipsilateral hearing loss, vertigo and nystagmus.
History and etymology
The syndrome was first described by Pierre Marie (1853-1940), Charles Foix (1882-1927), and Théophile Alajouanine (1890-1980), French neurologists, in 1922 3.
- 1. Kumral E, Bayülkem G, Evyapan D. Clinical spectrum of pontine infarction. Clinical-MRI correlations. J. Neurol. 2002;249 (12): 1659-70. doi:10.1007/s00415-002-0879-x - Pubmed citation
- 2. Nouh A, Remke J, Ruland S. Ischemic posterior circulation stroke: a review of anatomy, clinical presentations, diagnosis, and current management. Frontiers in neurology. 5: 30. doi:10.3389/fneur.2014.00030 - Pubmed
- 3. Marie P, Foix C, Alajouanine T. De I'atrophie cerebelleuse tardive a predominance corticale. Rev Neurol (Paris). 1922;29:1082-111.