Law of Bergonié and Tribondeau

The law of Bergonie and Tribondeau is that the radiosensitivity of a biological tissue is directly proportional to the mitotic activity and inversely proportional to the degree of differentiation of its cells. This law underpins the field of radiation-oncology, although such a general law may not apply precisely in all cases.

Usually neoplastic cells are more radiosensitive than the cells from which they originate; in fact, they reproduce much faster than healthy cells.

Cellular differentiation describes the extent to which a tumor resembles the normal tissue from which it derives. The more it differs from healthy tissue, the greater its radiosensitivity will be.

Radiation therapy

Article information

rID: 72348
Synonyms or Alternate Spellings:
  • Radiosensitivity law

ADVERTISEMENT: Supporters see fewers/no ads

Updating… Please wait.

 Unable to process the form. Check for errors and try again.

 Thank you for updating your details.