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Leborgne's law in mammography represents a classic clinical observation where the clinical (palpable) size of a malignant breast mass commonly exceeds the radiographic one 1. The peritumoral edema and/or desmoplastic reaction are thought to be the cause of this phenomenon.
The law has been described first by Raul Alfredo Leborgne Fossemale (1907–1986), an Uruguayan radiologist and pioneer in the field of mammography 2.
- 1. LEBORGNE R. Diagnosis of tumors of the breast by simple roentgenography; calcifications in carcinomas. (1951) The American journal of roentgenology and radium therapy. 65 (1): 1-11. Pubmed
- 2. R H Gold, L W Bassett, B E Widoff. Highlights from the history of mammography. (1990) RadioGraphics. 10 (6): 1111-31. doi:10.1148/radiographics.10.6.2259767 - Pubmed