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Leopard skin sign (white matter)

Last revised by Dr Mostafa El-Feky on 27 Dec 2021

The leopard skin sign (also known as tigroid pattern or stripe sign) results from dark spots or stripes (spared perivascular white matter) within bright demyelinated periventricular white matter on T2W images. It is characteristically seen in:

See also

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Cases and figures

  • Figure 1: leopard (photo)
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  • Case 1: metachromatic leukodystrophy
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  • Case 2: metachromatic leukodystrophy
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  • Case 3: metachromatic leukodystrophy
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