Last revised by Daniel J Bell on 13 Jun 2022

Leptospirosis results from infection by the zoonotic Leptospira spp. The condition can have multiorgan manifestations. Commonly affected organs include:

The term Weil disease (or syndrome) is reserved for a severe form of leptospirosis in which there is jaundice, often also accompanied by: uremia, anemia, a bleeding tendency, fever, and delirium. Other names used for this condition have included: Fiedler disease, icterohemorrhagic leptospirosis, and infectious or leptospiral jaundice.

Typically occurs as a biphasic illness:

  • acute phase: last 4-9 days
  • asymptomatic period: 1-3 days
  • late phase: 1-3 days

Weil disease was first described by Adolf Weil, a German physician (1848-1916) 3.

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