Leser-Trélat sign

Last revised by Dr Bahman Rasuli on 03 Jun 2020

The Leser-Trélat sign is a dermatological paraneoplastic syndrome referring to the explosive and rapid eruption of multiple seborrheic keratoses. It is associated with a number of different cancers including adenocarcinoma (e.g. gastric, colorectal), breast cancer, and lymphoproliferative disorders. The sign is a marker of advanced disease and is a poor prognostic marker 1.

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