Lesions of the corpus callosum

Last revised by Dr Yahya Baba on 28 Aug 2021

Lesions of the corpus callosum are uncommon and arise from multiple different etiologies. The lesions can be classified according to underlying pathophysiology 4-6.

Neoplasm

Typically, amongst neoplasms, only aggressive lesions can invade the corpus callosum as it is composed of very dense white matter tracts which act as a barrier to tumor spreading 1.

Vascular
Infection
Demyelination
Leukodystrophy
Congenital
Trauma
Other

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Cases and figures

  • Case 1: primary CNS lymphoma
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  • Case 2: glioblastoma
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  • Case 3: GBM involving the splenium
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  • Case 4: probable Marchiafava-Bignami
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  • Case 5: cavernous malformation
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  • Case 6: infarct
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