Leukaemia (CNS manifestations)

Dr Henry Knipe and Dr Bruno Di Muzio et al.

Leukaemia CNS manifestations can be divided into those related to the disease itself and those associated with its treatment. Leukaemias are haematologic malignancies in which occur a proliferation of haematopoietic cells at an undifferentiated or partially differentiated stage of maturation 1.

CNS manifestations directly attributed to leukaemia
Leukaemia treatment-related CNS complications
  • chemotherapy
    • drug-induced PRES 1
    • methotrexate neurotoxicity
      • aseptic meningitis
      • transverse myelopathy
      • stroke-like syndrome
      • demyelination and leukoencephalopathy
    • CNS infections due to immunosuppression (e.g. CNS aspergillosis and neurocandidiasis)
  • radiation therapy
  • bone marrow transplantation
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Article information

rID: 40055
Synonyms or Alternate Spellings:
  • CNS manifestations of leukaemia
  • Leukaemia: CNS complications
  • CNS complications of leukaemia

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Cases and figures

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    Case 1: infiltration of the optic nerve
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