Leukemia

Leukaemia is a haematological neoplasm characterised by the overproduction of immature (blasts) or abnormal leukocytesabnormally differentiated cells of the hematopoietic system in the bone marrow that often, but not always, extends into the peripheral blood. 

This article aims to provide an overview of leukaemia as an entity and how it is classified. For a further detailed discussion, including radiographic features, please refer to the specific articles on each subtype. Also, for the entire classification of haematological neoplasms, please refer to the article on "WHO classification of tumours of haematopoietic and lymphoid tissues".

General classification 

Leukaemia is classically divided according to the percentage of blasts in the bone marrow or peripheral blood:

• acute: when there is a proliferation of mostly immature/poorly differentiated cells (blasts) in the bone marrow (exceeding 20% of the bone marrow cell population)
  • clonal cells buildup crowds out the marrow in detriment of healthy blood lineage cells
  • disease becomes symptomatic early
• chronic: when there is a proliferation of mostly mature but abnormal leukocytes (abnormal leukocytosis) with or without associated cytopaenia

Specific classification 

The 2016 revised WHO classification has an extensive list of subtypes of leukaemia, this article will list the most prevalent ones. 

• acute lymphoblastic leukaemia (ALL)
  • commonly affecting children (~80% of leukaemias in this group) ³
• • usually severely symptomatic 
• chronic lymphocytic leukaemia (CLL)
  • commonly affecting elderly patients (mainly over 75 years) ²
• acute myeloid leukaemia (AML)
  • commonly seen in adults, but is also the second most common form affecting children ²
  • male predominance
• chronic myeloid leukaemia (CML)
  • commonly affecting male adults 
  • Philadelphia chromosome is present in 90% of cases ²

Systemic involvement 

• CNS manifestations
• pulmonary manifestations 
• testicular manifestations