Leukocoria

Leukocoria (also spelled as leucocoria or leukokoria) refers to an abnormal white reflection from the retina of the eye. Despite its color, the reflection is related to the familiar red-eye effect. Usually, when a light is shone through the iris, the retina appears red to the observer. In leukocoria, the retina abnormally appears white.

Pathology

Etiology

The top 4 causes of leukocoria are:

  1. retinoblastoma: ~58%
  2. persistent hyperplastic primary vitreous: ~28%
  3. Coats disease: ~16%
  4. larval granulomatosis: ~16%

As with anything, causes can be considered using a surgical sieve approach.

Tumors
Developmental
Infection
Degenerative
Trauma
Associations

Leukocoria can be seen in the normal-sized eye or associated with microphthalmia.

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Article information

rID: 5000
System: Head & Neck
Section: Gamuts
Tag: eye
Synonyms or Alternate Spellings:
  • Leucocoria

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Cases and figures

  • Figure 1: Photograph: leukocoria due to underlying retinoblastoma
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  • Case 1: Drusen of the optic nerve head
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  • Case 2: Persistent hyperplastic primary vitreous
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  • Case 3: Retinopathy of prematurity
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