Lewy bodies

Last revised by Frank Gaillard on 1 Oct 2021

Lewy bodies are intracellular cytoplasmic inclusions which result from abnormal alpha-synuclein metabolism (thus diseases with Lewy bodies are synucleinopathies). They also contain other proteins (ubiquitin and alpha B crystallin), fatty acids, sphingomyelin, and polysaccharides 1,2

Lewy bodies are found in:

  1. Parkinson disease
  2. Lewy body dementia

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Cases and figures

  • Lewy body (histology)
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