Light chain deposition disease

Light chain deposition disease (LCDD) is a rare disease. 

It can affect multiple organ systems. 

It mostly affects middle age patients and there is no recognised gender predilection

It is characterised by the deposition of a nonfibrillary, amorphous material that does not have β-pleated sheet configuration and consequently does not bind Congo red as amyloidosis. This eosinophilic material corresponds to monotypic immunoglobulin light chains deposits. The term “LCDD” is restricted to the nonamyloid forms of light chain deposition. Light chains are secreted by a clone of plasma cells

About 75% of LCDD occur in association with multiple myeloma or a lymphoproliferative disease, especially Waldenström's macroglobulinemia

The condition was recognized in 1976 by Randall.

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Article information

rID: 24848
System: Chest
Tag: cases, refs
Synonyms or Alternate Spellings:
  • Light chain deposition disease (LCCD)
  • LCCD

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