Light chain deposition disease (pulmonary manifestations)
Pulmonary manifestations of light chain deposition disease are rare when considering the full disease spectrum of light chain deposition disease.
The light chains are secreted by a plasma clone and deposit in the alveolar walls, small airways, and vessels.
HRCT manifestations most commonly include nodules, lymphadenopathy, and cysts. Cyst formation is believed to correspond to dilation of the small airways 1.
- 1; Seaman DM, Meyer CA, Gilman MD et-al. Diffuse cystic lung disease at high-resolution CT. AJR Am J Roentgenol. 2011;196 (6): 1305-11. doi:10.2214/AJR.10.4420 - Pubmed citation
- 2. Colombat M, Stern M, Groussard O et-al. Pulmonary cystic disorder related to light chain deposition disease. Am. J. Respir. Crit. Care Med. 2006;173 (7): 777-80. doi:10.1164/rccm.200510-1620CR - Pubmed citation
- 3. Colombat M, Gounant V, Mal H et-al. Light chain deposition disease involving the airways: diagnosis by fibreoptic bronchoscopy. Eur. Respir. J. 2007;29 (5): 1057-60. doi:10.1183/09031936.00134406 - Pubmed citation