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Liliequist membrane is an arachnoid membrane separating the chiasmatic cistern, interpeduncular cistern and prepontine cistern. It arises anteriorly from the diaphragma sellae and extends posteriorly separating into two sheets, although some authors delineate three discrete components 9.
One extends posterosuperiorly to the posterior edge of the mammillary body (known as the diencephalic membrane); it separates the suprasellar cistern from the interpeduncular cistern 8.
The second sheet extends posteroinferiorly to the pontomesencephalic junction (known as the mesencephalic membrane); it separates the interpeduncular and prepontine cisterns 8.
Laterally it is described as being attached to the oculomotor nerve (CN III), although there is some disagreement concerning the sites of the superior attachment and its lateral border 6.
The Liliequist membrane has neurosurgical importance, especially in endoscopic and microsurgery, and historically needed to be negotiated when performing pneumoencephalography 7.
Direct visualization of this membrane has until recently not been possible as it is very thin. Today, however, it can be visualized, in the vast majority of patients, on high-resolution heavily T2 weighted 3D sequences, usually constructive interference in steady state (CISS) sequences (e.g. FIESTA/FISP/FFE) 9.
History and etymology
It was originally described by Key and Retzius in 1875, and more precisely described by Liliequist in 1956 in his pneumoencephalographic work on cadavers 7,9.
- 1. Ward, John D. Radiology. doi:10.1148/radiol.2292030603
- 2. Lü J, Zhu XI. Microsurgical anatomy of Liliequist's membrane. Minim Invasive Neurosurg. 2003;46 (3): 149-54. doi:10.1055/s-2003-40743 - Pubmed citation
- 3. Zhang M, An PC. Liliequist's membrane is a fold of the arachnoid mater: study using sheet plastination and scanning electron microscopy. Neurosurgery. 2000;47 (4): 902-8. Neurosurgery (link) - Pubmed citation
- 4. Fushimi Y, Miki Y, Takahashi JA et-al. MR imaging of Liliequist's membrane. Radiat Med. 2006;24 (2): 85-90. - Pubmed citation
- 5. Jian Lü, Xian Li Zhu. Characteristics of distribution and configuration of intracranial arachnoid membranes. (2005) Surgical and Radiologic Anatomy. 27 (6): 472. doi:10.1007/s00276-005-0025-4 - Pubmed
- 6. Fushimi Y, Miki Y, Ueba T et-al. Liliequist membrane: three-dimensional constructive interference in steady state MR imaging. Radiology. 2003;229 (2): 360-5. doi:10.1148/radiol.2292021507 - Pubmed citation
- 7. Connor DE, Nanda A. Bengt Liliequist: life and accomplishments of a true renaissance man. (2017) Journal of neurosurgery. 126 (2): 645-649. doi:10.3171/2015.12.JNS131770 - Pubmed
- 8. Matsuno, Haruo, Rhoton, Albert L., Peace, David. Microsurgical Anatomy of the Posterior Fossa Cisterns. (1988) Neurosurgery. 23 (1): 58. doi:10.1227/00006123-198807000-00012 - Pubmed
- 9. Dias DA, Castro FL, Yared JH, Lucas Júnior A, Ferreira Filho LA, Ferreira NF. Liliequist membrane: radiological evaluation, clinical and therapeutic implications. (2014) Radiologia brasileira. 47 (3): 182-5. doi:10.1590/0100-3984.2013.1809 - Pubmed