Linear energy transfer
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Linear energy transfer (LET)
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Linear energy transfer (LET) is the average (radiation) energy deposited per unit path length along the track of an ionising particle. It'sIts units are keV/μm.
LETLinear energy transfer describes the energy deposition density of a particular type of radiation, which largely determines the biologicbiological consequence of radiation exposure.
LET is ∞ Q2/ E/Ek
- LET is proportional to the square of the charge of the particle
- LET is inversely proportional to the particle's kinetic energy
High LET radiations: LET 3-200 keV/μm
- low speed, highly charged particles
–: - greater density of interactions at cellular level
-
thereforemore likelyto, than low LET, to produce biological damage in a given volume of tissue(than low LET)
Low LET radiations: LET 0.2-3 keV/μm
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commonly mediated by:
- electrons
, - positrons
, - gamma
γ-rays &rays - x-rays
- electrons
- less likely than high LET to produce tissue damage in the same volume of tissue
-<p><strong>Linear energy transfer (LET)</strong> is the average (radiation) energy deposited per unit path length along the track of an ionising particle. It's units are keV/μm.</p><p>LET describes the energy deposition density of a particular type of radiation, which largely determines the biologic consequence of radiation exposure.</p><p>LET is ∞ Q<sup>2</sup>/ E<sub>k</sub></p><ul>- +<p><strong>Linear energy transfer (LET)</strong> is the average (radiation) energy deposited per unit path length along the track of an <a title="Ionising radiation" href="/articles/ionising-radiation">ionising particle</a>. Its units are keV/μm.</p><p>Linear energy transfer describes the energy deposition density of a particular type of radiation, which largely determines the biological consequence of radiation exposure.</p><p>LET is ∞ Q<sup>2</sup>/E<sub>k</sub></p><ul>
-</ul><p> </p><h6>High LET radiations: LET 3-200 keV/μm</h6><ul>-<li>low speed, highly charged particles – α-particles, protons, neutrons</li>- +</ul><h6>High LET radiations: LET 3-200 keV/μm</h6><ul>
- +<li>low speed, highly charged particles:<ul>
- +<li><a title="alpha particle" href="/articles/alpha-particle">α-particles</a></li>
- +<li><a title="protons" href="/articles/protons">protons</a></li>
- +<li><a title="neutrons" href="/articles/neutrons">neutrons</a></li>
- +</ul>
- +</li>
-<li>therefore more likely to produce biological damage in a given volume of tissue (than low LET)</li>- +<li>more likely, than low LET, to produce biological damage in a given volume of tissue</li>
-<li>electrons, positrons, gamma γ-rays & x-rays</li>-<li>less likely to produce tissue damage in the same volume of tissue</li>- +<li>commonly mediated by:<ul>
- +<li><a title="Electrons" href="/articles/electron">electrons</a></li>
- +<li>positrons</li>
- +<li>gamma rays</li>
- +<li><a title="X-rays" href="/articles/x-rays-1">x-rays</a></li>
- +</ul>
- +</li>
- +<li>less likely than high LET to produce tissue damage in the same volume of tissue</li>
References changed:
- 1. John C. P. Heggie, Neil A. Liddell, Kieran P. Maher. Applied Imaging Technology. (2020) <a href="https://books.google.co.uk/books?vid=ISBN9781875271337">ISBN: 9781875271337</a><span class="ref_v4"></span>
- 2. Jerrold T. Bushberg. The Essential Physics of Medical Imaging. (2012) <a href="https://books.google.co.uk/books?vid=ISBN9781451118100">ISBN: 9781451118100</a><span class="ref_v4"></span>
- 1. John C. P. Heggie, Neil A. Liddell, Kieran P. Maher. Applied Imaging Technology. (2020) ISBN: 9781875271337
- 2. Jerrold T. Bushberg. The Essential Physics of Medical Imaging. (2012) ISBN: 9781451118100.
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