Lipiodol® (also known as ethiodized oil) is an oil-based iodinated contrast medium that was historically used for myelography and hysterosalpingography. It was later superseded by newer, less hazardous, agents, and now is used primarily as a therapeutic agent. Guerbet is now the sole manufacturer of this agent.
Lipiodol comprises a combination of iodine and ethyl esters of poppy seed oil 6. The iodine is intercalated into the constituent fatty acids to produce a mixture of iodostearic and stearic-acid derived esters. The precise structure of Lipiodol has never been characterized 6.
- dacryocystography (DCG)
conventional transcatheter hepatic arterial chemoembolisation (cTACE) 3
- transcatheter radioembolization was initially developed using Lipiodol, but now non-Lipiodol drug-eluted glass or resin microspheres are preferred 4,5
Lipiodol radiolabeled with Re-188
Rhenium-188 Lipiodol is a radiopharmaceutical that can be used to treat patients with unresectable hepatocellular carcinoma. The final lipophilic complex, bis-(diethyldithiocarbamato) nitrido rhenium-188, to be administered through the hepatic artery, is as follows: Re-188 N (DEDC) 2-Lipiodol 7-10.
History and etymology
Lipiodol was discovered by the co-founders of the healthcare company Guerbet, Marcel Guerbet and Laurent Lafay in 1901 2. Indeed originally it was marketed as Lipiodol Lafay. It was originally developed as a therapeutic agent - a way to deliver iodine to tissues.
It was first employed in radiology in 1921 by Jean-Athanase Sicard and Jacques Forestier, French radiologists, who developed positive contrast myelography. This supplanted air myelography which had been used until then. Due to complications (e.g. chemical arachnoiditis) Lipiodol was itself superseded by iophendylate.
It was previously marketed as Ethiodol® in the US, but is now globally sold as Lipiodol.
- 1. Ronald L. Eisenberg. Radiology. (1994) ISBN: 9780815130529
- 2. Bonnemain B, Guerbet M. [The history of Lipiodol (1901-1994) or How a medication may evolve with the times]. (1995) Revue d'histoire de la pharmacie. 42 (305): 159-70. Pubmed
- 3. Salem R, Lewandowski RJ. Chemoembolization and radioembolization for hepatocellular carcinoma. (2013) Clinical gastroenterology and hepatology : the official clinical practice journal of the American Gastroenterological Association. 11 (6): 604-11; quiz e43-4. doi:10.1016/j.cgh.2012.12.039 - Pubmed
- 4. Sangro B, Iñarrairaegui M, Bilbao JI. Radioembolization for hepatocellular carcinoma. (2012) Journal of hepatology. 56 (2): 464-73. doi:10.1016/j.jhep.2011.07.012 - Pubmed
- 5. Poursaid A, Jensen MM, Huo E, Ghandehari H. Polymeric materials for embolic and chemoembolic applications. (2016) Journal of controlled release : official journal of the Controlled Release Society. 240: 414-433. doi:10.1016/j.jconrel.2016.02.033 - Pubmed
- 6. Yin X, Guo Y, Li W, Huo E, Zhang Z, Nicolai J, Kleps RA, Hernando D, Katsaggelos AK, Omary RA, Larson AC. Chemical shift MR imaging methods for the quantification of transcatheter lipiodol delivery to the liver: preclinical feasibility studies in a rodent model. (2012) Radiology. 263 (3): 714-22. doi:10.1148/radiol.12111916 - Pubmed
- 7. Boschi A, Uccelli L, Duatti A, Colamussi P, Cittanti C, Filice A, Rose AH, Martindale AA, Claringbold PG, Claringbold PG, Kearney D, Galeotti R, Turner JH, Turner HJ, Giganti M. A kit formulation for the preparation of 188Re-lipiodol: preclinical studies and preliminary therapeutic evaluation in patients with unresectable hepatocellular carcinoma. (2004) Nuclear medicine communications. 25 (7): 691-9. doi:10.1097/01.mnm.0000130241.22068.45 - Pubmed
- 8. Mallia MB, Chirayil V, Dash A. Improved freeze-dried kit for the preparation of ReN-DEDC/lipiodol for the therapy of unresectable hepatocellular carcinoma. (2018) Applied radiation and isotopes : including data, instrumentation and methods for use in agriculture, industry and medicine. 137: 147-153. doi:10.1016/j.apradiso.2018.03.018 - Pubmed
- 9. Wang SJ, Lin WY, Chen MN, Hsieh BT, Shen LH, Tsai ZT, Ting G, Knapp FF. Radiolabelling of Lipiodol with generator-produced 188Re for hepatic tumor therapy. (1996) Applied radiation and isotopes : including data, instrumentation and methods for use in agriculture, industry and medicine. 47 (3): 267-71. doi:10.1016/0969-8043(95)00300-2 - Pubmed
- 10. Richard P. Baum. Therapeutic Nuclear Medicine. (2014) ISBN: 9783540367192
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