Lipomyelocele, also known as lipomyeloschisis, is one of the most common closed spinal dysraphism. It is seen in thoracolumbar region and usually presents as a fatty subcutaneous mass.

It is twice as common as lipomyelomeningocele.

Affected individuals are usually asymptomatic at birth, but many (~ 50%) show presence of high-risk cutaneous markers as listed below:

  • hypertrichosis
  • atypical dimples
  • acrochordons (pseudo-tails)
  • lipomas
  • hemangiomas
  • aplasia cutis
  • dermoid cyst or sinus

As the spinal canal grows, there is a distortion of nerve roots with growth thereby leading to neurological deficits, highlighting the importance of early diagnosis.

There is a premature separation of surface ectoderm before formation of proper neural tube with the ingress of mesoderm (which forms fatty elements). The mesoderm prevents proper neurulation. 

Posterior spinal defect noted which is covered with skin and shows interspersed lipomatous tissue. The neural placode-lipoma interface lies within the spinal canal or at its edge with normal anterior subarachnoid space.

There is usually associated tethered low-lying cord or syrinx of terminal spinal cord.

Closed spinal dysraphism of thoracolumbar region presenting as subcutaneous mass may be due to:

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Article information

rID: 34511
Synonyms or Alternate Spellings:
  • Lipomyeloschisis
  • LMC
  • Lipoma with dural defect
  • Lipomyeloceles

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Cases and figures

  • Case 1
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  • Case 2
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  • Case 3: with tethered cord
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  • Case 4
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  • Case 5
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