As of the latest update, Google Chrome and Microsoft Edge have made a breaking change to how file uploads are handled. Once your system installs this update, you will not be able to upload new images. Please use another browser until we can get it fixed.

Liposclerosing myxofibrous tumor

Liposclerosing myxofibrous tumors (LSMFT), also known as polymorphic fibro-osseous lesions of bone, are rare benign fibro-osseous lesions that have a predilection for the intertrochanteric region of the femur.

It is slightly more common in males with mean age of 30-40 years old. It can be discovered incidentally but mostly patients have vague longstanding pain. About 10% of patients present acutely with pathologic fracture.

The tumor comprises of the wide mixture of tissues of lipomatous, fibroxanthomatous, myxomatous, and myxofibromatous components inclusive. 

Tends to have a striking predilection for the intertrochanteric region of the femur (80-90%) 1-3.

  • geographic lucent lesion usually centered in intertrochanteric region of the proximal femur
  • sclerotic margin
  • mildly expansile
  • multilocular
  • matrix calcification in ~70% of cases
  • fat density component

Despite its name distinct fatty components are not seen

  • T1: relatively homogeneous and isointense to skeletal muscle
  • T2: moderately heterogeneous with areas of high signal due to myxoid component

Scintigraphy can show mild focal uptake with 99Tc 1.

  • pathological fracture: uncommon ~10%
  • malignant transformation: rare but documented 10-15%; transformation into osteosarcoma is the most common

Due to this potential malignant transformation, lesions need follow-up imaging preferably by MRI. Symptomatic lesions or those with interval change require surgical resection 3.

On radiographs consider:

Bone tumours

The differential diagnosis for bone tumors is dependent on the age of the patient, with a very different set of differentials for the pediatric patient.

Share article

Article information

rID: 9663
Synonyms or Alternate Spellings:
  • Liposclerosing myxofibrous tumour (LSMFT)
  • LSMFT

Support Radiopaedia and see fewer ads

Cases and figures

  • Case 1: in right femur
    Drag here to reorder.
  •  Case 2
    Drag here to reorder.
  • Case 3
    Drag here to reorder.
  • Case 4
    Drag here to reorder.
  • Case 5
    Drag here to reorder.
  • Updating… Please wait.

     Unable to process the form. Check for errors and try again.

     Thank you for updating your details.