The liver is one of the most frequently damaged organs in blunt trauma, and liver trauma is associated with a significant mortality rate.
In blunt abdominal trauma, the liver is injured ~5% (range 1-10%) of the time 1,3.
Patients can present with right upper quadrant pain, right shoulder tip pain (from diaphragmatic irritation), hypotension and shock 3.
The mechanism for liver trauma can be from blunt (e.g. motor vehicle collision, fall, direct blow, etc.) or penetrating trauma (e.g. gunshot, stabbing). It can also be iatrogenic (e.g. percutaneous liver biopsy).
Most (~80%) of liver injuries are minor (grades I to III). There is a range of injuries:
- laceration (most common)
- haematoma - subcapsular or intraparenchymal
- active haemorrhage
- major hepatic vein injury
- AV fistula
- bile duct injury
Approximately 80% of the liver injuries are associated with other abdominal injuries 1,3.
Within the liver:
- lacerations that involve a hepatic vein are associated with increased risk of arterial injury and need for operative management 8
- although not an injury, periportal edema can be seen associated with liver injuries as patients with higher grade injuries will have received aggressive fluid resuscitation
- lacerations that extend to the porta hepatis increase the risk of bile duct injuries, particularly delayed biliary complications 8
- bile duct injuries are more common in 9:
- higher grade injuries
- central injuries, that is injuries that are close to the IVC
- penetrating trauma, compared with blunt trauma
Outside the liver (known as secondary signs):
- lacerations that extend to the bare area can be associated with a retroperitoneal haematoma or an adrenal haemorrhage
- right lower lobe pulmonary contusion/laceration
- right sided rib fractures
- transverse process fractures
- right kidney injury
Elevated liver transaminases (ALT/AST) is 100% specific and ~93% sensitive in predicting liver injuries 4,6.
CT is the investigation of choice for evaluating for liver trauma. It is ~95% sensitive and 99% specific for detecting liver injuries 5.
- lacerations appear as irregular linear/branching areas of hypoattenuation
- haematomas appear as a hypodensity between the liver and its capsule (and can be differentiated from intra-peritoneal haematoma as these distort the liver architecture) or can be intraparenchymal
- acute haematomas/haemorrhage are typically hyperdense (40-60HU) compared to normal liver parenchyma
- muscular diaphragmatic slips may simulate a peripheral laceration but are smoother, non-branching and of muscle density when compared to a laceration
If the liver is diffusely hypoattenuating, such as seen in steatosis, lacerations and haematomata may be more subtle to diagnose 8. Secondary signs should help.
See main article liver injury grading for more details.
Scintigraphy, such as that using Tc-99m mebrofenin or disofenin, is the most commonly used test for the diagnosis of bile leaks 9. A contained leak will demonstrate an extrabiliary focus of radiotracer which remains stable in size and morphology during all the phases of the study. A free intraperitoneal bile leak will demonstrate an extraluminal collection of radiotracer in the peritoneal cavity that varies or increases in time 9.
Several mimics of liver lacerations and haematomata exist, and include 8:
- focal fat infiltration
- unenhanced aberrant portal or hepatic veins
- congenital fissures and clefts: typically fat density, and in usualy locations
- diaphragmatic slips or eventration: identifiable on coronal images
- pre-existing liver lesions
Treatment and prognosis
Most (>80%) of liver injuries can be treated non-surgically, and in blunt trauma relies on haemodynamic stability rather than a grade of injury 4-5. There is a significant mortality rate of ~8% (range 4.1-11.7%) associated with liver trauma 1. Complications are reported in ~20% of cases of non-operatively treated liver trauma 7:
- 1. Yoon W, Jeong YY, Kim JK et-al. CT in blunt liver trauma. Radiographics. 2005;25 (1): 87-104. Radiographics (full text) - doi:10.1148/rg.251045079 - Pubmed citation
- 2. Poletti PA, Mirvis SE, Shanmuganathan K et-al. CT criteria for management of blunt liver trauma: correlation with angiographic and surgical findings. Radiology. 2000;216 (2): 418-27. doi:10.1148/radiology.216.2.r00au44418 - Pubmed citation
- 3. Romano L, Giovine S, Guidi G et-al. Hepatic trauma: CT findings and considerations based on our experience in emergency diagnostic imaging. Eur J Radiol. 2004;50 (1): 59-66. doi:10.1016/j.ejrad.2003.11.015 - Pubmed citation
- 4. Hassan R, Abd Aziz A. Computed Tomography (CT) Imaging of Injuries from Blunt Abdominal Trauma: A Pictorial Essay. Malays J Med Sci. 2012;17 (2): 29-39. Free text at pubmed - Pubmed citation
- 5. Ahmed N, Vernick JJ. Management of liver trauma in adults. J Emerg Trauma Shock. 2011;4 (1): 114-9. doi:10.4103/0974-2700.76846 - Free text at pubmed - Pubmed citation
- 6. Ritchie AH, Williscroft DM. Elevated liver enzymes as a predictor of liver injury in stable blunt abdominal trauma patients: case report and systematic review of the literature. Can J Rural Med. 2007;11 (4): 283-7. Pubmed citation
- 7. Emergency Radiology. Springer. (2007) ISBN:3540689087. Read it at Google Books - Find it at Amazon
- 8. Graves JA, Hanna TN, Herr KD. Pearls and pitfalls of hepatobiliary and splenic trauma: what every trauma radiologist needs to know. Emergency radiology. doi:10.1007/s10140-017-1515-5 - Pubmed
- 9. LeBedis CA, Anderson SW, Mercier G, Kussman S, Coleman SL, Golden L, Penn DR, Uyeda JW, Soto JA. The utility of CT for predicting bile leaks in hepatic trauma. (2015) Emergency radiology. 22 (2): 101-7. doi:10.1007/s10140-014-1262-9 - Pubmed