Localized tenosynovial giant cell tumor
Citation, DOI & article data
Localized tenosynovial giant cell tumors is a subtype that is most commonly found in the fingers. On imaging, these lesions are commonly demonstrated as localized, solitary, subcutaneous soft tissue nodules, with low T1 and T2 signal and moderate enhancement.
Please see the overview article tenosynovial giant cell tumor for content common to both the localized-type and diffuse-type.
Typically, they present in the 3rd to 5th decades and have a slight female predilection with an F:M ratio of 1.5-2.1:1 4,13. They are the second most common soft tissue mass of the hand and wrist.
Clinically, localized tenosynovial giant cell tumors present as a slow-growing, painless mass 13.
Localized tenosynovial giant cell tumors are most common in the fingers (~85%) where they are close to a tendon sheath or interphalangeal joint. Less commonly they can be found in the the wrist, ankle, foot, knee, and are rarely found in the elbow and hip 13. Localized tenosynovial giant cell tumors can be extra-articular (more common) or intra-articular 13.
Localized tenosynovial giant cell tumors are usually lobulated, well-cirumscribed masses between 0.5-4 cm and are white-to-grey with yellowish and brown regions 13.
See main tenosynovial giant cell tumor article.
Tenosynovial giant cell tumors appear as soft tissue density peri-articular masses and can cause pressure erosion of adjacent bone, or rarely can invade the bone mimicking an intraosseous lesion 8,13. Periosteal reaction and calcification are uncommon 4,5.
Ultrasound is useful as it allows not only the characterization of the lesion but also is able to demonstrate the relationship with the adjacent tendon. On the dynamic scan, there is free movement of the tendon within the lesion. Typically they appear as:
associated with the volar surface of the digits
does not move with flexion or extension of adjacent tendons
usually homogeneously hypoechoic, although some heterogeneity may be seen in echotexture in a minority of cases 1
most will have some internal vascularity
Localized type are a single mass with a capsule and small low intensity foci representing faint hemosiderin deposition 14. Bone erosion and neurovascular encasement can be seen 14.
T1: low signal
T2: low signal
T1 C+ (Gd): often show moderate enhancement 6
GE: low and may demonstrate blooming artifact
Treatment and prognosis
Tenosynovial giant cell tumors are usually benign and local surgical excision usually suffices, with local recurrence (seen in 4-30% of cases) requiring more extensive surgery with or without radiotherapy being uncommon 1,13. Locally aggressive and malignant tenosynovial giant cell tumors can occur 11. Metastases can occur, most commonly to lymph nodes and lung 4.
See main tenosynovial giant cell tumor article.
- 1. Middleton W, Patel V, Teefey S, Boyer M. Giant Cell Tumors of the Tendon Sheath: Analysis of Sonographic Findings. AJR Am J Roentgenol. 2004;183(2):337-9. doi:10.2214/ajr.183.2.1830337 - Pubmed
- 2. Ly J, Carlson C, LaGatta L, Beall D. Giant Cell Tumor of the Peroneus Tendon Sheath. AJR Am J Roentgenol. 2003;180(5):1442. doi:10.2214/ajr.180.5.1801442 - Pubmed
- 3. Jelinek J, Kransdorf M, Shmookler B, Aboulafia A, Malawer M. Giant Cell Tumor of the Tendon Sheath: MR Findings in Nine Cases. AJR Am J Roentgenol. 1994;162(4):919-22. doi:10.2214/ajr.162.4.8141018 - Pubmed
- 4. Murphey M, Rhee J, Lewis R, Fanburg-Smith J, Flemming D, Walker E. Pigmented Villonodular Synovitis: Radiologic-Pathologic Correlation. Radiographics. 2008;28(5):1493-518. doi:10.1148/rg.285085134 - Pubmed
- 5. Peh W, Shek T, Ip W. Growing Wrist Mass. Ann Rheum Dis. 2001;60(6):550-3. doi:10.1136/ard.60.6.550 - Pubmed
- 6. Bassetti E, Candreva R, Santucci E. Giant Cell Tumor of the Flexor Tendon of the Wrist: US and MRI Evaluation. Case Report. J Ultrasound. 2011;14(1):37-9. doi:10.1016/j.jus.2010.12.001 - Pubmed
- 7. Gude W & Morelli V. Ganglion Cysts of the Wrist: Pathophysiology, Clinical Picture, and Management. Curr Rev Musculoskelet Med. 2008;1(3-4):205-11. doi:10.1007/s12178-008-9033-4 - Pubmed
- 8. Wang C, Duan Q, Xue Y et al. Giant Cell Tumour of Tendon Sheath with Bone Invasion in Extremities: Analysis of Clinical and Imaging Findings. Radiol Med. 2015;120(8):745-52. doi:10.1007/s11547-015-0520-6 - Pubmed
- 9. Wang Y, Tang J, Luo Y. The Value of Sonography in Diagnosing Giant Cell Tumors of the Tendon Sheath. J Ultrasound Med. 2007;26(10):1333-40. doi:10.7863/jum.2007.26.10.1333 - Pubmed
- 10. Christopher D. M. Fletcher. WHO Classification of Tumours of Soft Tissue and Bone. (2013) ISBN: 9789283224341 - Google Books
- 11. Plotkin B, Sampath S, Sampath S, Motamedi K. MR Imaging and US of the Wrist Tendons. Radiographics. 2016;36(6):1688-700. doi:10.1148/rg.2016160014 - Pubmed
- 12. Llauger J, Palmer J, Rosón N, Cremades R, Bagué S. Pigmented Villonodular Synovitis and Giant Cell Tumors of the Tendon Sheath: Radiologic and Pathologic Features. AJR Am J Roentgenol. 1999;172(4):1087-91. doi:10.2214/ajr.172.4.10587152 - Pubmed
- 13. Dei Tos A, Somerhausen N, Rijn M, Tenosynovial giant cell tumour. In: WHO Classification of Tumours Editorial Board. Soft tissue and bone tumours. Lyon (France): International Agency for Research on Cancer; 2020. (WHO classification of tumours series, 5th ed.; vol. 3). https://publications.iarc.fr
- 14. Jeong H, Lee S, Kim J, Yoo C, Joo M, Kim J. Tenosynovial Giant Cell Tumors of Digits: MRI Differentiation Between Localized Types and Diffuse Types with Pathology Correlation. Skeletal Radiol. 2022;:1-11. doi:10.1007/s00256-022-04170-x - Pubmed