Citation, DOI, disclosures and article data
At the time the article was created Behnam Shayegi had no recorded disclosures.View Behnam Shayegi's current disclosures
At the time the article was last revised Daniel J Bell had no recorded disclosures.View Daniel J Bell's current disclosures
For a general discussion, and for links to other system-specific manifestations, please refer to the article on syphilis.
Syphilitic aortitis takes place during the stage of tertiary syphilis between 5 to 30 years after initiation of primary syphilis. This is normally due to infection of the aorta secondary to endarteritis obliterans of the vasa vasorum.
The aortic wall becomes progressively weakened due to chronic inflammation. This will subsequently lead to aneurysm (10%), coronary artery narrowing at its ostium (30%), and aortic valve insufficiency secondary to the involvement of the aortic valve.
- extensive thickening of aortic wall with periaortic inflammation
- asymmetrical aortic sinus involvement
- saccular aneurysms and heavily calcified ascending aorta
- "tree bark" intimal calcifications due to intimal wrinkling
- saccular asymmetric aortic aneurysm
- aortic root branches involvement
The aneurysm diameter is often not accurately measured by using angiography. This is normally due to intra-aneurysmal / mural thrombosis and calcification, layering of the contrast, and magnification.
Treatment and prognosis
High-dose antibiotics and resection of enlarging aneurysm.
History and etymology
The term "lues" is an old name for syphilis, derived from Latin lues for "filth".
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