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At the time the article was created Yuranga Weerakkody had no recorded disclosures.View Yuranga Weerakkody's current disclosures
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Lung carcinosarcomas are uncommon malignant biphasic tumors classified as a subtype of sarcomatoid tumors of the lung.
It is rare and thought to account for <1% of all lung cancers. There may be a greater male predilection with tumor generally occurring in heavy smokers with peak occurrence between the 5th to 8th decades of life 1.
It is defined by coexisting histologic elements of carcinomatous (typically squamous cell carcinoma or adenocarcinoma) and sarcomatous components (eg. rhabdomyosarcoma, chondrosarcoma, and osteosarcoma).
- TP53 mutations are often present 4
- KRAS mutations are less frequent 4
- EGFR mutations are very uncommon 4
Treatment and prognosis
Overall prognosis is generally considered poor 1. Some authors suggest carcinomatous portion tending to metastasize to regional lymph nodes whereas the sarcomatous part favoring systemic dissemination 2.
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- 2. Shyu HL, Huang BS, Cheng CY, Wu JK, Wang LS, Hsu WH, Tao CW, Li WY, Huang MH, Chien KY. Carcinosarcoma of the lung: an analysis of 6 operated cases. (1994) Zhonghua yi xue za zhi = Chinese medical journal; Free China ed. 53 (6): 363-8. Pubmed
- 3. Gulbanu Horzum Ekinci, Osman Haciomeroglu, Serda Kanbur Metin, Ayse Ersev, Pinar Atagun Guney, Çagatay Tezel, Adnan Yilmaz. Clinicopathological characteristics and treatment outcomes of pulmonary carcinosarcoma in eight patients. (2015) European Respiratory Journal. doi:10.1183/13993003.congress-2015.PA4308
- 4. Travis WD, Brambilla E, Nicholson AG, Yatabe Y, Austin JHM, Beasley MB, Chirieac LR, Dacic S, Duhig E, Flieder DB, Geisinger K, Hirsch FR, Ishikawa Y, Kerr KM, Noguchi M, Pelosi G, Powell CA, Tsao MS, Wistuba I. The 2015 World Health Organization Classification of Lung Tumors: Impact of Genetic, Clinical and Radiologic Advances Since the 2004 Classification. (2015) Journal of thoracic oncology : official publication of the International Association for the Study of Lung Cancer. 10 (9): 1243-1260. doi:10.1097/JTO.0000000000000630 - Pubmed