Lupus anticoagulant
Last revised by Joshua Yap on 1 Jun 2023
Citation, DOI, disclosures and article data
Citation:
Weerakkody Y, Yap J, Luong D, Lupus anticoagulant. Reference article, Radiopaedia.org (Accessed on 29 Mar 2024) https://doi.org/10.53347/rID-66391
Permalink:
rID:
66391
Article created:
18 Feb 2019,
Yuranga Weerakkody ◉
Disclosures:
At the time the article was created Yuranga Weerakkody had no recorded disclosures.
View Yuranga Weerakkody's current disclosures
Last revised:
Disclosures:
At the time the article was last revised Joshua Yap had no financial relationships to ineligible companies to disclose.
View Joshua Yap's current disclosures
Revisions:
3 times, by
3 contributors -
see full revision history and disclosures
Systems:
Synonyms:
- Lupus anticoagulant (LAC)
Lupus anticoagulant refers to an immunoglobulin that binds to phospholipids and proteins associated with cell membranes. The name lupus "anticoagulant" is in fact a misnomer as it is a prothrombotic agent. Patients with lupus anticoagulant have a primary hypercoagulable state and a greater propensity for thrombosis.
References
- 1. Molad Y, Sidi Y, Gornish M, Lerner M, Pinkhas J, Weinberger A. Lupus anticoagulant: correlation with magnetic resonance imaging of brain lesions. (1992) The Journal of rheumatology. 19 (4): 556-61. Pubmed
- 2. Vittorio Pengo, Alessandra Biasiolo, Paolo Gresele, Francesco Marongiu, Nicoletta Erba, Fabio Veschi, Angelo Ghirarduzzi, Doris Barcellona, Armando Tripodi. A Comparison of Lupus Anticoagulant–Positive Patients With Clinical Picture of Antiphospholipid Syndrome and Those Without. (2007) Arteriosclerosis, Thrombosis, and Vascular Biology. 27 (12): e309-10. doi:10.1161/ATVBAHA.107.153536 - Pubmed
- 3. Matthew R. Kovacs, Alejandro Lazo-Langner, Martha L Louzada, Michael J. Kovacs. Long Term Monitoring of Patients with Positive Lupus Anticoagulant and Antiphospholipid Antibodies. Are All Cases Persistently Positive?. (2016) Blood. 128 (22): 1452.