Luxury perfusion

Dr Henry Knipe et al.

Luxury perfusion or hyperperfusion describes the return of cerebral blood flow to normal or increased levels in regions of infarcted brain and is thought to occur secondary to blood brain barrier permeability and dysfunctional autoregulation. It most commonly occurs in subacute strokes but has been reported in acute (<24 hours) strokes 1,2

Radiographic features


On CT perfusion, these regions will manifest as regions of elevated cerebral blood volume (CBV) and cerebral blood flow (CBF), as well as prolonged mean transit time (MTT) and time to peak (TTP). Corresponding non-contrast CT should show changes of an established stroke 1

Differential diagnosis

Patients presenting with stroke-like symptoms post-seizure (e.g. Todd paresis) can have a similar pattern of hyperperfusion with increased CBV and CBF, and in patients with motor and speech deficits prolonged MTT 3

Stroke and intracranial haemorrhage

Article information

rID: 57188
Synonyms or Alternate Spellings:
  • Luxury hyperperfusion

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