Lymphoid thymic hyperplasia
Lymphoid thymic hyperplasia is a form of thymic hyperplasia.
Unlike in true thymic hyperplasia, there is a presence of an increased number of lymphoid follicles
This condition is most commonly associated with conditions such as
- autoimmune conditions
- myasthenia gravis: may be seen in up to 65% of cases
- immunologically mediated disorders
Some publications (with small sample sizes) suggest that CT attenuation of lymphoid hyperplasia can be significantly higher than that of true hyperplasia, with the optimal threshold of of around 40 HU useful for differentiating lymphoid hyperplasia from true thymic hyperplasia 3.
- 1. Nishino M, Ashiku SK, Kocher ON, Thurer RL, Boiselle PM, Hatabu H. The thymus: a comprehensive review. (2006) Radiographics : a review publication of the Radiological Society of North America, Inc. 26 (2): 335-48. doi:10.1148/rg.262045213 - Pubmed
- 2. Priola AM, Priola SM, Ciccone G, Evangelista A, Cataldi A, Gned D, Pazè F, Ducco L, Moretti F, Brundu M, Veltri A. Differentiation of rebound and lymphoid thymic hyperplasia from anterior mediastinal tumors with dual-echo chemical-shift MR imaging in adulthood: reliability of the chemical-shift ratio and signal intensity index. (2015) Radiology. 274 (1): 238-49. doi:10.1148/radiol.14132665 - Pubmed
- 3. Araki T, Sholl LM, Gerbaudo VH, Hatabu H, Nishino M. Imaging characteristics of pathologically proven thymic hyperplasia: identifying features that can differentiate true from lymphoid hyperplasia. (2014) AJR. American journal of roentgenology. 202 (3): 471-8. doi:10.2214/AJR.13.11210 - Pubmed
- 4. Minato H, Kinoshita E, Nakada S, Nojima T, Tanaka M, Usuda K, Sagawa M, Iwao H, Tanaka M, Doai M, Takahashi T, Shibata N. Thymic lymphoid hyperplasia with multilocular thymic cysts diagnosed before the Sjögren syndrome diagnosis. (2015) Diagnostic pathology. 10: 103. doi:10.1186/s13000-015-0332-y - Pubmed
- 5. McErlean A, Huang J, Zabor EC, Moskowitz CS, Ginsberg MS. Distinguishing benign thymic lesions from early-stage thymic malignancies on computed tomography. (2013) Journal of thoracic oncology : official publication of the International Association for the Study of Lung Cancer. 8 (7): 967-73. doi:10.1097/JTO.0b013e3182904bc2 - Pubmed