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Lymphoma (staging)

Last revised by Henry Knipe ◉ on 10 Dec 2024

Citation, DOI, disclosures and article data

Citation:

Gaillard F, Knipe H, Campos A, et al. Lymphoma (staging). Reference article, Radiopaedia.org (Accessed on 10 Dec 2024) https://doi.org/10.53347/rID-1457

DOI:

https://doi.org/10.53347/rID-1457

Permalink:

https://radiopaedia.org/articles/1457

rID:

1457

Article created:

2 May 2008, Frank Gaillard ◉ ◈

Disclosures:

At the time the article was created Frank Gaillard had no recorded disclosures.

View Frank Gaillard's current disclosures

Last revised:

10 Dec 2024, Henry Knipe ◉

Disclosures:

At the time the article was last revised Henry Knipe had the following disclosures:

Micro-X Ltd, Shareholder (past)

These were assessed during peer review and were determined to not be relevant to the changes that were made.

View Henry Knipe's current disclosures

Revisions:

32 times, by 20 contributors - see full revision history and disclosures

Systems:

Haematology, Oncology

Sections:

Staging

Synonyms:

Hodgkin's lymphoma staging
Staging of lymphoma
Staging of Hodgkin lymphoma

Many lymphoma staging systems for Hodgkin and non-Hodgkin lymphoma have been developed.

Usage

The Lugano staging classification is commonly used in clinical practice and research (c. 2023) ¹⁰. It also separately defines criteria for response to treatment assessed by PET-CT or CT alone. Patients having undergone immunomodulatory therapy may also be assessed by a modification of the Lugano criteria called LYRIC, which introduces the category of "indeterminate response."

Classification

Evolution of lymphoma staging and treatment response evaluation criteria:

1950: Peters three-part system ⁸
1966: Rye staging system ⁷
1971: Ann Arbor staging system
1989: Cotswolds modifications of the Ann Arbor staging system with the introduction of the use of computed tomography (CT)
1999: International Working Group Response Criteria: five clinical response categories based on lesion sizes
2007: International Harmonization Project Criteria: CT evaluation with additional use of relative qualitative evaluation F-18 FDG PET-CT
2009: Deauville five-point scale: qualitative evaluation with graduation of F-18 FDG uptake on PET-CT
2009: Positron Emission Tomography Response Criteria in Solid Tumours (PERCIST) for non-Hodgkin lymphoma (and also non-lymphoma tumours) ⁹
2014: Lugano classification
2016: lymphoma response to immunomodulatory therapy criteria (LYRIC)

References

1. Cronin C, Swords R, Truong M et al. Clinical Utility of PET/CT in Lymphoma. AJR Am J Roentgenol. 2010;194(1):W91-W103. doi:10.2214/AJR.09.2637 - Pubmed
2. Hopper K, Diehl L, Lesar M, Barnes M, Granger E, Baumann J. Hodgkin Disease: Clinical Utility of CT in Initial Staging and Treatment. Radiology. 1988;169(1):17-22. doi:10.1148/radiology.169.1.3420256 - Pubmed
3. Cheson B, Fisher R, Barrington S et al. Recommendations for Initial Evaluation, Staging, and Response Assessment of Hodgkin and Non-Hodgkin Lymphoma: The Lugano Classification. J Clin Oncol. 2014;32(27):3059-68. doi:10.1200/JCO.2013.54.8800 - Pubmed
4. Toma P, Granata C, Rossi A, Garaventa A. Multimodality Imaging of Hodgkin Disease and Non-Hodgkin Lymphomas in Children. Radiographics. 2007;27(5):1335-54. doi:10.1148/rg.275065157 - Pubmed
5. Kwee T, Kwee R, Nievelstein R. Imaging in Staging of Malignant Lymphoma: A Systematic Review. Blood. 2008;111(2):504-16. doi:10.1182/blood-2007-07-101899 - Pubmed
6. Johnson S, Kumar A, Matasar M, Schöder H, Rademaker J. Imaging for Staging and Response Assessment in Lymphoma. Radiology. 2015;276(2):323-38. doi:10.1148/radiol.2015142088 - Pubmed
7. Rosenberg, S.A. (1966) Report of the committee on the staging of Hodgkin's disease. Cancer Research, 26, 1310
8. Aisenberg A. Historical Review of Lymphomas. Br J Haematol. 2000;109(3):466-76. doi:10.1046/j.1365-2141.2000.01988.x - Pubmed
9. O J, Lodge M, Wahl R. Practical PERCIST: A Simplified Guide to PET Response Criteria in Solid Tumors 1.0. Radiology. 2016;280(2):576-84. doi:10.1148/radiol.2016142043 - Pubmed
10. Ricard F, Cheson B, Barrington S et al. Application of the Lugano Classification for Initial Evaluation, Staging, and Response Assessment of Hodgkin and Non-Hodgkin Lymphoma: The PRoLoG Consensus Initiative (Part 1—Clinical). J Nucl Med. 2022;64(1):102-8. doi:10.2967/jnumed.122.264106 - Pubmed

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Lymphoma (staging)

Citation, DOI, disclosures and article data

Usage

Classification

References

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