Lymphomatoid granulomatosis (LG), also known as angiocentric lymphoma or angiocentric immunoproliferative lesion, is a rare type of non-Hodgkin's lymphoma.
There is a recognised association with antecedent infection with the Epstein Barr virus (EBV).
It can affect a variety of organs.
- lung involvement: ~80% of cases 4
- skin (cutaneous) involvement: 33-50% 2,4
- CNS involvement: 20% 2
Radiographic features are discussed separately:
- pulmonary manifestations of lymphomatoid granulomatosis
- CNS manifestations of lymphomatoid granulomatosis
- cutaneous manifestations of lymphomatoid granulomatosis
History and etymology
It was Initially described by Leibow et al. in 1972 5.
- 1. Wechsler RJ, Steiner RM, Israel HL et-al. Chest radiograph in lymphomatoid granulomatosis: comparison with Wegener granulomatosis. AJR Am J Roentgenol. 1984;142 (1): 79-83. AJR Am J Roentgenol (abstract) - Pubmed citation
- 2. Dee PM, Arora NS, Innes DJ. The pulmonary manifestations of lymphomatoid granulomatosis. Radiology. 1982;143 (3): 613-8. Radiology (abstract) - Pubmed citation
- 3. Mccloskey M, Catherwood M, Mcmanus D et-al. A case of lymphomatoid granulomatosis masquerading as a lung abscess. Thorax. 2004;59 (9): 818-9. doi:10.1136/thx.2003.008094 - Free text at pubmed - Pubmed citation
- 4. Lee JS, Tuder R, Lynch DA. Lymphomatoid granulomatosis: radiologic features and pathologic correlations. AJR Am J Roentgenol. 2000;175 (5): 1335-9. AJR Am J Roentgenol (full text) - Pubmed citation
- 5. Liebow AA, Carrington CR, Friedman PJ. Lymphomatoid granulomatosis. Hum. Pathol. 1972;3 (4): 457-558. - Pubmed citation
- overview of lymphoma
WHO classification of tumours of haematopoietic and lymphoid tissues
- Hodgkin lymphoma
- mature B-cell lymphoma
- mature T-cell and NK-cell lymphoma
- post-transplant lymphoproliferative/lymphoproliferation disorders
- location-specific lymphomas
- central nervous system
- head and neck lymphoma
- thoracic lymphoma
- gastrointestinal lymphoma
- hepatobiliary lymphoma
- genitourinary lymphoma
- musculoskeletal lymphoma
- cutaneous lymphoma
- lymphoma staging