Lymphopenia

Last revised by Daniel J Bell on 17 Jul 2020

Citation, DOI, disclosures and article data

Citation:

Bell D, Lymphopenia. Reference article, Radiopaedia.org (Accessed on 06 Aug 2024) https://doi.org/10.53347/rID-75600

DOI:

https://doi.org/10.53347/rID-75600

Permalink:

https://radiopaedia.org/articles/75600?iframe=true

rID:

75600

Article created:

2 Apr 2020, Daniel J Bell ◉

Disclosures:

At the time the article was created Daniel J Bell had no recorded disclosures.

View Daniel J Bell's current disclosures

Last revised:

17 Jul 2020, Daniel J Bell ◉

Disclosures:

At the time the article was last revised Daniel J Bell had no recorded disclosures.

View Daniel J Bell's current disclosures

Revisions:

2 times, by 1 contributor - see full revision history and disclosures

Systems:

Haematology

Synonyms:

Lymphocytopenia
Sublymphaemic
Sublymphaemia
Hypolymphaemic
Hypolymphaemia
Secondary lymphopenia
Lymphocytopenias
Secondary lymphopenias
Lymphopenias
Primary lymphopenias
Primary lymphopenia
Decreased blood lymphocyte number
Lymphopaenia
Lymphopaenias

Lymphopenia (also known as lymphocytopenia, hypolymphaemia and sublymphaemia) is a deficiency of circulating lymphocytes ¹. It may be either primary or secondary.

Terminology

The spelling lymphopaenia is erroneous and should never be used.

Pathology

Aetiology

Primary

primary immunodeficiencies ³
- a heterogeneous group of disorders with a large number of genetic mutations

Secondary

infections (commonest cause)
- mycobacteria: predominantly TB
- viral
  - HIV
  - CMV
  - EBV
  - HBV
  - HTLV-1
  - COVID-19
- parasites
  - malaria
malignancy
- non-Hodgkin lymphoma (NHL)
- myelodysplastic syndrome (MDS)
autoimmune
- Sjogren disease
- SLE
drugs
- steroids
- chemotherapeutic agents
- cytotoxics