Lymphoplasmacytic lymphoma

Last revised by Ali Alsmair on 16 Mar 2022

Lymphoplasmacytic lymphoma (LPL) is an uncommon type of B-cell non-Hodgkin lymphoma. In this condition, the affected tissues (usually bone marrow) become infiltrated by small lymphocytes, plasmacytoid lymphocytes, and plasma cells. 

Some publications state this condition synonymous with Waldenström macroglobulinemia while others state the latter as a subtype of lymphoplasmacytic lymphoma 1 where is bone marrow involvement and production of IgM monoclonal proteins.

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