Lysosomal storage disorders

Lysosomal storage disorders (LSD) form a large group of clinical entities, more than forty now described, with the common etiological theme being the presence of dysfunctional lysosomal proteins, with the secondary accumulation of toxic metabolites inside the cellular lysosomes.


The prevalence of these individual disorders ranges from 1 in 57 000 for Gaucher disease to 1 in 4.2 million for sialidosis 2. As a group of disorders the prevalence is 1 per 7 700 live births 2.

Inborn errors of metabolism
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Article information

rID: 68999
Synonyms or Alternate Spellings:
  • Lysosomal storage disorder
  • Disorders of lysosomal storage
  • Lysosomal storage disorders (LSDs)
  • Lysosomal storage disorders (LSD)

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