Macklin effect
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The Macklin effect describes one of the pathophysiological processprocesses of pneumomediastinum in blunt chest trauma. The Macklin effect accounts for ~40% of severe blunt traumatic pneumomediastinum. Exclusion of tracheobronchial and oesophageal causes of pneumomediastinum is mandatory to exclude concomitant injury 1.
Pathology
The proposed mechanism is alveolar rupture with air dissecting along peribronchovascular interstitial sheaths, interlobular septa, visceral pleura and into the mediastinum 1.
Radiographic features
CT
Pulmonary interstitial emphysema with air tracking along the bronchovascular sheaths towards the hilum and associated pneumomediastinum.
History and etymology
The pathophysiologic process was first proposed by C C Macklin in 1939 2.
-<p>The<strong> Macklin effect</strong> describes one of the pathophysiological process of <a href="/articles/pneumomediastinum">pneumomediastinum</a> in blunt chest trauma. The Macklin effect accounts for ~40% of severe blunt traumatic pneumomediastinum. Exclusion of <a title="Tracheobronchial injury" href="/articles/tracheobronchial-injury">tracheobronchial</a> and <a title="Oesophageal injury" href="/articles/oesophageal-perforation">oesophageal</a> causes of pneumomediastinum is mandatory to exclude concomitant injury <sup>1</sup>.</p><h4>Pathology</h4><p>The proposed mechanism is alveolar rupture with air dissecting along peribronchovascular interstitial sheaths, interlobular septa, visceral pleura and into the mediastinum <sup>1</sup>.</p><h4>Radiographic features</h4><h5>CT</h5><p>Pulmonary interstitial emphysema with air tracking along the bronchovascular sheaths towards the hilum and associated pneumomediastinum. </p><h4>History and etymology</h4><p>The pathophysiologic process was first proposed by <strong>C C Macklin</strong> in 1939 <sup>2</sup>.</p>- +<p>The<strong> Macklin effect</strong> describes one of the pathophysiological processes of <a href="/articles/pneumomediastinum">pneumomediastinum</a> in blunt chest trauma. The Macklin effect accounts for ~40% of severe blunt traumatic pneumomediastinum. Exclusion of <a href="/articles/tracheobronchial-injury">tracheobronchial</a> and <a href="/articles/oesophageal-perforation">oesophageal</a> causes of pneumomediastinum is mandatory to exclude concomitant injury <sup>1</sup>.</p><h4>Pathology</h4><p>The proposed mechanism is alveolar rupture with air dissecting along peribronchovascular interstitial sheaths, interlobular septa, visceral pleura and into the mediastinum <sup>1</sup>.</p><h4>Radiographic features</h4><h5>CT</h5><p>Pulmonary interstitial emphysema with air tracking along the bronchovascular sheaths towards the hilum and associated pneumomediastinum. </p><h4>History and etymology</h4><p>The pathophysiologic process was first proposed by <strong>C C Macklin</strong> in 1939 <sup>2</sup>.</p>