Macklin effect
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- updated 3 May 2022:
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The Macklin effect describes one of the pathophysiological processes of pneumomediastinum in blunt chest trauma. The Macklin This effect accounts for the formation of ~40% of severe blunt traumatic pneumomediastinum. Exclusion of tracheobronchial and oesophageal causes of pneumomediastinum is mandatory to exclude concomitant injury.
Pathology
The mechanism proposed mechanism is anby Macklin was alveolar rupture with air dissecting along peribronchovascular interstitial sheaths, interlobular septa, and the visceral pleura into the mediastinum 1.
Radiographic features
CT
Pulmonary interstitial emphysema with air tracking along the peribronchovascular sheaths towards the hilum and associated pneumomediastinum.
History and etymology
The pathophysiologic process was first proposed by C C Macklin in 1939 2.
-<p>The<strong> Macklin effect</strong> describes one of the pathophysiological processes of <a href="/articles/pneumomediastinum">pneumomediastinum</a> in blunt chest trauma. The Macklin effect accounts for ~40% of severe blunt traumatic pneumomediastinum. Exclusion of <a href="/articles/tracheobronchial-injury">tracheobronchial</a> and <a href="/articles/oesophageal-perforation">oesophageal</a> causes of pneumomediastinum is mandatory to exclude concomitant injury.</p><h4>Pathology</h4><p>The proposed mechanism is an alveolar rupture with air dissecting along <a href="/articles/peribronchovascular-interstitium">peribronchovascular interstitial</a> sheaths, <a href="/articles/interlobular-septa">interlobular septa</a>, and the <a href="/articles/pleura">visceral pleura</a> into the <a href="/articles/mediastinum-1">mediastinum</a> <sup>1</sup>.</p><h4>Radiographic features</h4><h5>CT</h5><p>Pulmonary interstitial emphysema with air tracking along the peribronchovascular sheaths towards the <a href="/articles/lung-hilum">hilum</a> and associated pneumomediastinum. </p><h4>History and etymology</h4><p>The pathophysiologic process was first proposed by <strong>C C Macklin</strong> in 1939 <sup>2</sup>.</p>- +<p>The<strong> Macklin effect</strong> describes one of the pathophysiological processes of <a href="/articles/pneumomediastinum">pneumomediastinum</a> in blunt chest trauma. This effect accounts for the formation of ~40% of severe blunt traumatic pneumomediastinum. Exclusion of <a href="/articles/tracheobronchial-injury">tracheobronchial</a> and <a href="/articles/oesophageal-perforation">oesophageal</a> causes of pneumomediastinum is mandatory to exclude concomitant injury.</p><h4>Pathology</h4><p>The mechanism proposed by Macklin was alveolar rupture with air dissecting along <a href="/articles/peribronchovascular-interstitium">peribronchovascular interstitial</a> sheaths, <a href="/articles/interlobular-septa">interlobular septa</a>, and the <a href="/articles/pleura">visceral pleura</a> into the <a href="/articles/mediastinum-1">mediastinum</a> <sup>1</sup>.</p><h4>Radiographic features</h4><h5>CT</h5><p><a title="Pulmonary interstitial emphysema" href="/articles/pulmonary-interstitial-emphysema">Pulmonary interstitial emphysema</a> with air tracking along the peribronchovascular sheaths towards the <a href="/articles/lung-hilum">hilum</a> and associated pneumomediastinum. </p><h4>History and etymology</h4><p>The pathophysiologic process was first proposed by <strong>C C Macklin</strong> in 1939 <sup>2</sup>.</p>
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