Citation, DOI, disclosures and article data
At the time the article was created Charlie Chia-Tsong Hsu had no recorded disclosures.View Charlie Chia-Tsong Hsu's current disclosures
At the time the article was last revised Hillel S. Maresky had no financial relationships to ineligible companies to disclose.View Hillel S. Maresky's current disclosures
The Macklin effect describes one of the pathophysiological processes of pneumothorax and pneumomediastinum in blunt chest trauma. This effect accounts for the formation of ~40% of severe blunt traumatic pneumomediastinum. Exclusion of tracheobronchial and esophageal causes of pneumomediastinum is mandatory to exclude concomitant injury.
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The mechanism proposed by Macklin was alveolar rupture with air dissecting along peribronchovascular interstitial sheaths, interlobular septa, and the visceral pleura into the mediastinum 1.
Pulmonary interstitial emphysema with air tracking along the peribronchovascular sheaths towards the hilum and associated pneumomediastinum.
History and etymology
The pathophysiologic process was first proposed by C C Macklin in 1939 2.
- 1. Wintermark M & Schnyder P. The Macklin Effect: A Frequent Etiology for Pneumomediastinum in Severe Blunt Chest Trauma. Chest. 2001;120(2):543-7. doi:10.1378/chest.120.2.543 - Pubmed
- 2. Macklin CC. Transport of air along sheaths of pulmonic blood vessels from alveoli to mediastinum: clinical implications. Arch Intern Med 1939; 64:913–926
- 3. Murayama S & Gibo S. Spontaneous Pneumomediastinum and Macklin Effect: Overview and Appearance on Computed Tomography. World J Radiol. 2014;6(11):850-4. doi:10.4329/wjr.v6.i11.850 - Pubmed